229981-33-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 100-39-0 benzyl bromide 
• 160002-06-2 (S)-tert-butyl 3-oxo-1-phenylhex-5-en-2-ylcarbamate 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 129778-76-3 (2S,3R)-1-phenyl-2-[N-(tert-butoxycarbonyl)amino]-5-hexen-3-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1337862-68-6 tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-1-phenylhex-5-en-2-ylcarbamate 
• 229981-28-6 (3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(tert-butyldimethylsilyloxy)-5-phenylpent-1-ene 
• 229981-17-3 (4S,5R)-N-(tert-butyloxycarbonyl)-5-ethenyl-4-phenylmethyl oxazolidin-2-one 
• 99113-30-1 ((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester 
• 124915-64-6 (4S,5R)-5-ethenyl-4-phenylmethyloxazolidin-2-one 
• 229981-31-1 (3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(tert-butyldimethylsilyloxy)-1-hydroxy-5-phenylpentane 

Downstream Products

• 109579-10-4 (4S,5S)-5-Benzyl-1-(tert-butyloxycarbonyl)-4-hydroxypyrrolidin-2-one 
• 129029-33-0 (4R,5S)-5-Benzyl-4-hydroxy-2-oxopyrrolidine 
• 129029-32-9 (4S,5S)-5-Benzyl-2-oxo-4-hydroxypyrrolidine 
• 109579-09-1 (5S)-5-benzyl-4-hydroxy-1-t-butoxycarbonylpyrrol-2(5H)-one 
• 72155-49-8 N-(tert-butoxycarbonyl)-4(S)-amino-3(R)-hydroxy-5-phenylpentanoic acid 
• 178113-66-1 (3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoic acid 
• 175550-95-5 (2S,3S)-tert-butyl 2-benzyl-3-((tert-butyldimethylsilyl)oxy)-5-oxopyrrolidine-1-carboxylate 
• 651359-09-0 (2S,3S,5R)-2-benzyl-3-((tert-butyldimethylsilyl)oxy)-1-methyl-5-nonylpyrrolidine 
• 125356-66-3 (+)-preussin 
• 159542-04-8 (-)-hapalosin 

Relevant academic research and scientific papers

An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (?)-hapalosin

A diastereoselective approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones 1 (P1 = TBS, P2 = H) has been developed through a stereoselective tandem Barbier process of (R,SRS)-8 with alkyl and aryl bromide. The stereochemistry at the C-5 stereogenic center of the trans-4-hydroxy-5-substituted 2-pyrrolidinones was solely controlled by α-alkoxy substitution. This effective approach was successfully used to prepare a variety of substituted (3R,4S)-statines 2. In addition, two bioactive natural products of (+)-preussin 4 and hapalosin 5 were effectively synthesized through this stereoselective tandem Barbier process.

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine

An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride 3 and antiangiogenic streptopyrrolidine 4. Compared four s