129779-76-6

Upstream product

• 100-39-0 benzyl bromide 
• 117168-59-9 (2S,3S,4R)-2-azido-1,3,4-octadecanetriol 
• 129779-75-5 (2R,3S,4R)-1,3,4-tri-O-benzyl-2-O-methansulfonyl-5-octadecene-1,2,3,4-tetraol 
• 1053640-18-8 (S)-((4S,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-thiazol-2-yl-methanol 
• 1053616-39-9 1-((1R,2R,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-heptadecyloxymethyl)-4-methoxy-benzene 
• 1053623-18-9 2-[(S)-((4R,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-methyl]-thiazole 
• 1053262-98-8 (S)-((4R,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde 
• 1054736-10-5 (R)-2-((4R,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethanol 
• 1053645-45-6 (2R,3R,4R)-2-(4-Methoxy-benzyloxy)-octadecane-1,3,4-triol 
• 1027176-14-2 ((4R,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-thiazol-2-yl-methanone 
• 1053270-21-5 2,2-Dimethyl-propionic acid (4S,5R)-2,2-dimethyl-5-tetradecyl-[1,3]dioxolan-4-ylmethyl ester 
• 1054649-33-0 2,2-Dimethyl-propionic acid (2S,3R)-2,3-dihydroxy-heptadecyl ester 
• 1027896-10-1 (4R,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolane-4-carbaldehyde 
• 1053638-97-3 (2S,3R)-heptadecane-1,2,3-triol 

Downstream Products

• 129779-78-8 (2S,3S,4R)-1,3,4-tri-O-benzyl-N-tetracosanoyl-2-amino-1,3,4-octadecanetriol 
• 209899-68-3 (2S,3S,4R)-2-(N-hexacosanoylamino)-3,4-di-O-benzoyl-1,3,4-octadecanetriol 
• 1053701-00-0 (2S,3S,4R)-2-(N-hexacosanoylamino)-1-O-(triphenylmethyl)-1,3,4-octadecanetriol 
• 148289-66-1 C₅₈H₉₅NO₈ 
• 164988-99-2 Acetic acid (R)-1-((1S,2S,3R)-2,3-dihydroxy-1-trityloxymethyl-heptadecylcarbamoyl)-tricosyl ester 
• 1054644-79-9 Hexacosanoic acid ((1S,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-heptadecyl)-amide 
• 164989-00-8 Acetic acid (R)-1-((1S,2S,3R)-2,3-dihydroxy-1-trityloxymethyl-heptadecylcarbamoyl)-pentacosyl ester 
• 164988-85-6 Acetic acid (R)-1-((1S,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-heptadecylcarbamoyl)-tricosyl ester 
• 164988-86-7 Acetic acid (R)-1-((1S,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-heptadecylcarbamoyl)-pentacosyl ester 
• 209899-67-2 (2S,3S,4R)-2-(N-hexacosanoylamino)-3,4-di-O-benzoyl-1-O-(triphenylmethyl)-1,3,4-octadecanetriol 
• 164989-07-5 C₇₇H₁₀₉NO₈ 
• 164989-08-6 C₇₉H₁₁₃NO₈ 
• 129779-77-7 (2S,3S,4R)-1,3,4-tri-O-benzyl-2-amino-1,3,4-octadecanetriol 

Relevant academic research and scientific papers

Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000

(Chemical Equation) The synthesis of 4-deoxy-4,4-difluoro-KRN7000 starting from phytosphingosine is described. Key steps include a regioselective benzylation of azidophytosphingosine and a deoxofluor-mediated fluorination of the corresponding 4-ketone. Th

Structure-activity relationship of α-galactosylceramides against b16- bearing mice

Agelasphin-9b, (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-16-methyl-2-[N- ((R)-2-hydroxytetracosanoyl)-amino]-1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and the relationship between their structures and biological activities was examined using several assay systems. From the results, KRN7000, (2S,3S,4R)-1-O-(α- D-galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol, was selected as a candidate for clinical application.

Total Synthesis of (2S,3S,4R)-2--16-methylheptadecane-1,3,4-triol 3,4-dibenzoate, a Partially Protected Ceramide Part of Sponge Cerebrosides

(2S,3S,4R)-2--16-methylheptadecane-1,3,4-triol 3,4-dibenzoate 32, apertially protected ceramide part of a cerebroside from the marine sponge Halichondria japonica, has been synthesized from L-ascorbic acid, and its absolute stereochemistry has been determined.The key steps in the synthesis include the regioselective ring opening of chiral epoxide 5 with a 2-alkyl-2-lithio-1,3-dithiane and the introduction of a hydroxymethylene synthon using Dondoni's protocol to assemble C(1) and C(2) functionality.

Total Synthesis of (2S,3S,4R)-N-Tetracosanoyl-2-amino-1,3,4-octadecanetriol, a Ceramide Part of Wheat Flour Glycosyl Ceramides

The synthesis of (2S,3S,4R)-N-tetracosanoyl-2-amino-1,3,4-octadecanetriol (5) was achieved in eight steps in a 23 percent overall yield starting from 3,4,6-tri-O-benzyl-D-galactopyranose (6), and then ceramide 5 was converted to (2S,3S,4R)-3,4-di-O-benzoy