129789-91-9

Upstream product

• 92584-63-9 3-(3-bromophenoxy)propan-1-ol 
• 64-17-5 ethanol 
• 18386-03-3 3-(3-bromophenoxy)propionic acid 
• 591-20-8 3-Bromophenol 
• 100-85-6 N-benzyl-trimethylammonium hydroxide 
• 140-88-5 ethyl acrylate 

Downstream Products

• 1429323-80-7 C₁₇H₂₅BO₅ 
• 1429323-81-8 C₃₄H₄₇N₅O₉ 
• 1429323-82-9 C₁₇H₁₉N₅O₃ 

Relevant academic research and scientific papers

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

MACROCYCLIC LRRK2 KINASE INHIBITORS

The present invention relates to novel macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease

Heterocyclic retinoid compounds

The current invention provide novel heterocyclic retinoid compounds, methods of treating or preventing chronic obstructive pulmonary disease, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of thes

Condensed heterocyclic compounds

The invention relates to compounds of the formula STR1 wherein R1 is hydrogen, acyl, lower-alkyl or --CHO, --CH2 OR10, --COR7 or OR13 ; R2, R3 and R4 are, independently, hydrogen, lower-alkyl, lower-alkoxy or halogen; R5 and R6 are, independently, hydrogen or lower-alkyl; R7 is hydroxy, lower-alkoxy or NR8 R9 ; R8 and R9 are, independently, hydrogen or lower-alkyl; X and Y are, independently, >CR14 R15, --O--, --S--, >SO, >SO2 or >NR18 ; R10 and R18 are, independently, hydrogen, lower-alkyl or acyl; M is --C(R11)=C(R12)--, --CONH-- or --NH--CO--; R11, R12, R14 and R15 are, independently, hydrogen or lower-alkyl, R13 is hydrogen, lower-alkoxycarbonyl or lower- alkyl, which can be substituted by amino, mono-alkylamino, di-alkylamino, morpholino, thiomorpholino or piperazino; and n is 1, 2, 3 or 4; with the proviso that at least one of X and Y comprises a hetero atom and n is 1, 3 or 4 when X contains a hetero atom, Y is >C(CH3)2 and R1 is lower-alkyl or --CH2 OR10 or --COR7, or a salt of a compound of formula I, when R1 is carboxy. The compounds of formula I are useful in the treatment of prophylaxis of neoplasms, dermatoses and ageing of the skin.