92584-63-9Relevant academic research and scientific papers
Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP3 prostanoid receptor
Gallant,Carriere,Chateauneuf,Denis,Gareau,Godbout,Greig,Juteau,Lachance,Lacombe,Lamontagne,Metters,Rochette,Ruel,Slipetz,Sawyer,Tremblay,Labelle
, p. 2583 - 2586 (2002)
Potent and selective ligands for the human EP3 prostanoid receptor are described. Biaryl compounds bearing a tethered ortho substituted acidic moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinity of key compounds on all eight human prostanoid receptors is reported.
Biphenyl compound as well as preparation method and medical application thereof
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Paragraph 0782-0788; 0938-0944; 0938-0944, (2020/11/22)
The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.
MACROCYCLIC LRRK2 KINASE INHIBITORS
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Page/Page column 79, (2013/04/13)
The present invention relates to novel macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease
