92584-63-9Relevant articles and documents
Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP3 prostanoid receptor
Gallant,Carriere,Chateauneuf,Denis,Gareau,Godbout,Greig,Juteau,Lachance,Lacombe,Lamontagne,Metters,Rochette,Ruel,Slipetz,Sawyer,Tremblay,Labelle
, p. 2583 - 2586 (2002)
Potent and selective ligands for the human EP3 prostanoid receptor are described. Biaryl compounds bearing a tethered ortho substituted acidic moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinity of key compounds on all eight human prostanoid receptors is reported.
MACROCYCLIC LRRK2 KINASE INHIBITORS
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Page/Page column 79, (2013/04/13)
The present invention relates to novel macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease