1298023-90-1

Basic information

• Product Name: (2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester
• Synonyms: (2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester;DKQDRVXNPGKIGU-UHFFFAOYSA-N
• CAS NO: 1298023-90-1
• Molecular Formula: C12H19NO4S
• Molecular Weight: 273.34856
• Product Categories: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1298023-90-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester(1298023-90-1)
• EPA Substance Registry System: (2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester(1298023-90-1)

Safety Data

• Hazardous Substances Data: 1298023-90-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear Oil

Uses

(2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester is an intermediate in the preparation of rac-Vigabatrin Hydrochloride (V253010), (-)-Sessilifoliamide C and (-)-8-Epi-stemoamide.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1298024-11-9 (5S)-pyrrolidin-2-one-5-carbothioic acid ethyl ester 
• 98-79-3 L-Pyroglutamic acid 
• 53100-44-0 L-N-t-butoxycarbonylpyroglutamic acid 
• 75-08-1 ethanethiol 

Downstream Products

• 1428733-28-1 tert-butyl (1S,6R)-3-formyl-6-hydroxycyclohex-3-enylcarbamate 
• 1428733-29-2 ethyl (4R,5S)-5-(tert-butoxycarbonylamino)-4-hydroxycyclohex-1-enecarboxylate 
• 1428733-31-6 ethyl (4R,5S)-5-(tert-butoxycarbonylamino)-4-(methylsulfonyloxy)cyclohex-1-enecarboxylate 
• 950690-19-4 ethyl (S)-5-((tert-butoxycarbonyl)amino)cyclohexa-1,3-diene-1-carboxylate 
• 1428733-30-5 (4R,5S)-5-(tert-butoxycarbonylamino)-4-hydroxycyclohex-1-enecarboxylic acid 
• 96914-00-0 (S)-5-oxopyrrolidine-2-carbaldehyde 

Relevant articles and documents

AMIDE DERIVATIVE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF

An amide derivative inhibitor and a preparation method and an application thereof. Specifically relating to the compound shown in general formula (I), a preparation method for same, a pharmaceutical composition comprising said compound, and an application of same as an ASK inhibitor for the treatment of neurodegenerative disease, cardiovascular disease, inflammation, autoimmune and metabolic disease, each of the substituents in the general formula (I) being as defined in the description.

Total synthesis of (-)-sessilifoliamide C and (-)-8-epi-stemoamide

A convergent route featuring [3,3]-sigmatropic rearrangements of a linchpin azepinopyrrolidine served to install two of the four contiguous stereocenters present in the tricyclic Stemona alkaloids sessilifoliamide and stemoamide. In addition to the first total synthesis of (-)-sessilifoliamide C, a potential biosynthetic relationship between the sessilifoliamides and previously reported Stemona alkaloids is presented.