1299474-17-1

Basic information

• Product Name: 1-BroMo-2-(ethanesulfonyl)benzene
• Synonyms: 1-BroMo-2-(ethanesulfonyl)benzene;1-bromo-2-(ethylsulfonyl)benzene
• CAS NO: 1299474-17-1
• Molecular Formula: C₈H₉BrO₂S
• Molecular Weight: 249.12486
• Mol File: 1299474-17-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BroMo-2-(ethanesulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BroMo-2-(ethanesulfonyl)benzene(1299474-17-1)
• EPA Substance Registry System: 1-BroMo-2-(ethanesulfonyl)benzene(1299474-17-1)

Safety Data

• Hazardous Substances Data: 1299474-17-1(Hazardous Substances Data)

Usage

Structure

Benzene ring with a bromine atom and an ethanesulfonyl group attached

Physical State

Clear, colorless liquid

Odor

Strong, pungent

Uses

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Manufacturing of dyes and pigments

Hazards

a. Potential irritant to skin
b. Potential irritant to eyes
c. Potential irritant to respiratory system
d. Harmful if ingested

Safety Precautions

Handle with care, store and dispose of properly

Upstream product

• 74-96-4 ethyl bromide 
• 6320-02-1 o-bromothiophenol 
• 87424-98-4 1-bromo-2-ethylsulfanylbenzene 
• 75-03-6 ethyl iodide 
• 2905-25-1 o-bromobenzenesulfonyl chloride 

Relevant articles and documents

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

FLAP MODULATORS

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, R2, R3, R3′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention

Palladium-catalysed direct heteroarylation of bromobenzenes bearing SO 2R substituents at C2 or C4

Palladium-catalysed direct arylation of 4- or 2-bromobenzenesulfonic acid derivatives in the presence of a variety of heteroaromatics was found to proceed using 0.1-0.5 mol% palladium acetate as the catalyst. However, both the nature and position of the SO2R substituent on such bromobenzenes has an influence on the reaction rates and yields. The presence of SO2Et or SO2NEt2 at the C2 or C4 position of bromobenzene is tolerated. Good results were also obtained from bromobenzene substituted at C4 by SO2NHPh or SO2OPh. On the other hand, the reactions of bromobenzenes bearing either SO2N(Me)CH2Ph or SO 2OAr at C2 led in some cases to intramolecular reactions instead of the desired intermolecular couplings. Some reactions were performed in cyclopentyl methyl ether, which can be considered as a green solvent.