129995-63-7Relevant articles and documents
A Covenient Preparation of Triazolopyridines from Acetohydrazide Derivatives. Synthetic and Mechanistic Aspects
Callejo, Maria J.,Lafuente, Pilar,Martin-Leon, Nazario,Quinteiro, Margarita,Seoane, Carlos,Soto, Jose L.
, p. 1687 - 1690 (2007/10/02)
A novel synthesis of triazolopyridines (4) from 2'-acetyl-2-cyanoacetohydrazide (2) and arylidenemalononitriles (3) is described.The synthesis can be carried out either in one step or via 1-acetamidopyridones (5).Alternatively, acetylation of 1-aminopyridones (7) also gives triazolopyridines (4).Reaction of (2) with (3) in the presence of piperidine leads to the piperidinium salt of the triazolopyridine (6), which can be neutralized to give (4).