55819-76-6

Basic information

• Product Name: cyanoacetic 2-acetylhydrazide
• Synonyms: cyanoacetic 2-acetylhydrazide;3-(2-Acetylhydrazino)-3-oxopropanenitrile;N'-Acetyl-2-cyanoacetohydrazide;N'-Acetylcyanoacetohydrazide
• CAS NO: 55819-76-6
• Molecular Formula: C₅H₇N₃O₂
• Molecular Weight: 141.13
• Mol File: 55819-76-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 462.4°Cat760mmHg
• Flash Point: 233.5°C
• Appearance: /
• Density: 1.213g/cm³
• CAS DataBase Reference: cyanoacetic 2-acetylhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: cyanoacetic 2-acetylhydrazide(55819-76-6)
• EPA Substance Registry System: cyanoacetic 2-acetylhydrazide(55819-76-6)

Safety Data

• Hazardous Substances Data: 55819-76-6(Hazardous Substances Data)

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 129995-64-8 7-(p-methoxyphenyl)-2-methyl-5-oxo-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-59-1 1-acetamido-6-amino-4-(p-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 124443-23-8 2-methyl-5-oxo-7-phenyl-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-66-0 1-acetamido-6-amino-2-oxo-4-phenyl-2,3,4,5-tetrahydropyridine-3,5-dicarbonitrile 
• 129995-63-7 2-methyl-5-oxo-7-p-tolyl-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-58-0 1-acetamido-6-amino-2-oxo-4-p-tolyl-1,2-dihydropyridine-3,5-dicarbonitrile 
• 129995-65-9 7-(p-chlorophenyl)-2-methyl-5-oxo-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-60-4 1-acetamido-6-amino-4-(p-chlorophenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 130781-63-4 2-(5-methyl-1,3,4-oxadiazol-2-yl)acetonitrile 
• 1444020-41-0 N-(4-(5-amino-3-hydroxy-1H-pyrazol-1-yl)-3-cyanothiophen-2-yl)-2-cyano-2-(4-hydroxy-3-phenylthiazol-2(3H)-ylidene)acetamide 
• 1444020-39-6 4-amino-5-benzoyl-N-(4-(5-amino-3-hydroxy-1Hpyrazol-1-yl)-3-ethoxycarbonylthiophen-2-yl)-2-(phenylamino)thiophene-3-carboxamide 
• 1444020-36-3 5-acetyl-4-amino-N-(4-(5-amino-3-hydroxy-1H-pyrazol-1-yl)-3-ethoxycarbonyl-thiophen-2-yl)-2-(phenylamino)thiophene-3-carboxamide 
• 1444020-34-1 4-amino-5-benzoyl-N-(4-(5-amino-3-hydroxy-1H-pyrazol-1-yl)-3-cyanothiophen-2-yl)-2-(phenylamino)thiophene-3-carboxamide 
• 1444020-32-9 5-acetyl-4-amino-N-(4-(5-amino-3-hydroxy-1Hpyrazol-1-yl)-3-cyanothiophen-2-yl)-2-(phenylamino)thiophene-3-carboxamide 

Relevant articles and documents

THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE

Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

A Covenient Preparation of Triazolopyridines from Acetohydrazide Derivatives. Synthetic and Mechanistic Aspects

A novel synthesis of triazolopyridines (4) from 2'-acetyl-2-cyanoacetohydrazide (2) and arylidenemalononitriles (3) is described.The synthesis can be carried out either in one step or via 1-acetamidopyridones (5).Alternatively, acetylation of 1-aminopyridones (7) also gives triazolopyridines (4).Reaction of (2) with (3) in the presence of piperidine leads to the piperidinium salt of the triazolopyridine (6), which can be neutralized to give (4).

Synthesis and reactions of 2(5)-[benzyl or cyanomethyl]-1,3,4-oxadiazoles

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