55819-76-6

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 124443-25-0 Piperidinium 6,8-Dicyano-2-methyl-5-oxo-7-phenyl-1,2,4-triazolo<1,5-a>pyridinide 
• 129995-64-8 7-(p-methoxyphenyl)-2-methyl-5-oxo-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-59-1 1-acetamido-6-amino-4-(p-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 124443-23-8 2-methyl-5-oxo-7-phenyl-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-66-0 1-acetamido-6-amino-2-oxo-4-phenyl-2,3,4,5-tetrahydropyridine-3,5-dicarbonitrile 
• 129995-63-7 2-methyl-5-oxo-7-p-tolyl-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-58-0 1-acetamido-6-amino-2-oxo-4-p-tolyl-1,2-dihydropyridine-3,5-dicarbonitrile 
• 129995-65-9 7-(p-chlorophenyl)-2-methyl-5-oxo-3,5-dihydro-<1,2,4>triazolo<1,5-a>pyridine-6,8-dicarbonitrile 
• 129995-60-4 1-acetamido-6-amino-4-(p-chlorophenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 130781-63-4 2-(5-methyl-1,3,4-oxadiazol-2-yl)acetonitrile 
• 15119-34-3 3-cyanocoumarin 
• 1444020-20-5 N-(4-(5-amino-3-hydroxy-1H-pyrazol-1-yl)-3-cyanothiophen-2-yl)-α-phenyl-hydrazono-2-cyanoacetamide 
• 1444020-22-7 N-(4-(5-amino-3-hydroxy-1H-pyrazol-1-yl)-3-cyanothiophen-2-yl)-α-(p-methylphenylhydrazono)-2-cyanoacetamide 
• 1444020-24-9 N-(4-(5-amino-3-hydroxy-1H-pyrazol-1-yl)-3-cyanothiophen-2-yl)-α-(p-chlorophenylhydrazono)-2-cyanoacetamide 

Relevant academic research and scientific papers

THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE

Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

SUBSTITUTED BENZENE COMPOUNDS

The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

A Covenient Preparation of Triazolopyridines from Acetohydrazide Derivatives. Synthetic and Mechanistic Aspects

A novel synthesis of triazolopyridines (4) from 2'-acetyl-2-cyanoacetohydrazide (2) and arylidenemalononitriles (3) is described.The synthesis can be carried out either in one step or via 1-acetamidopyridones (5).Alternatively, acetylation of 1-aminopyridones (7) also gives triazolopyridines (4).Reaction of (2) with (3) in the presence of piperidine leads to the piperidinium salt of the triazolopyridine (6), which can be neutralized to give (4).