1300689-96-6Relevant articles and documents
Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site
Dubiella, Christian,Cui, Haissi,Gersch, Malte,Brouwer, Arwin J.,Sieber, Stephan A.,Krüger, Achim,Liskamp, Rob M. J.,Groll, Michael
, p. 11969 - 11973 (2014)
The concept of proteasome inhibition ranks among the latest achievements in the treatment of blood cancer and represents a promising strategy for modulating autoimmune diseases. In this study, we describe peptidic sulfonyl fluoride inhibitors that selecti
Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap
Brouwer, Arwin J.,Ceylan, Tarik,Jonker, Anika M.,Linden, Tima Van Der,Liskamp, Rob M.J.
, p. 2397 - 2406 (2011/05/12)
We have designed and synthesized novel irreversible serine protease inhibitors containing aliphatic sulfonyl fluorides as an electrophilic trap. These substituted taurine sulfonyl fluorides derived from taurine or protected amino acids were conveniently s