13007-85-7

Basic information

• Product Name: SODIUM GLUCOHEPTONATE
• Synonyms: SODIUM A-GLUCOHEPTONATE;SODIUM A-D-GLUCOHEPTONATE;SODIUM-ALPHA-GLUCOHEPTONATE;SODIUM ALPHA-D-GLUCOHEPTONATE;SODIUM HEPTAGLUCONATE;SODIUM GLUCO HEPTANATE;D-Glycero-D-gulo-heptonicacid,monosodiumsalt;gluceptate
• CAS NO: 13007-85-7
• Molecular Formula: C7H13NaO8
• Molecular Weight: 248.16
• EINECS: 235-849-8
• Mol File: 13007-85-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 727.8 °C at 760 mmHg
• Flash Point: 407.9 °C
• Appearance: /
• Density: 1.6[at 20℃]
• Vapor Pressure: 1.87E-24mmHg at 25°C
• Storage Temp.: −20°C
• Water Solubility: 564g/L
• CAS DataBase Reference: SODIUM GLUCOHEPTONATE(CAS DataBase Reference)
• NIST Chemistry Reference: SODIUM GLUCOHEPTONATE(13007-85-7)
• EPA Substance Registry System: SODIUM GLUCOHEPTONATE(13007-85-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13007-85-7(Hazardous Substances Data)

Usage

Uses

Pharmaceutic aid.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C7H14O8.Na/c8-1-2(9)3(10)4(11)5(12)6(13)7(14)15;/h2-6,8-13H,1H2,(H,14,15);/q;+1/p-1/t2-,3-,4+,5-,6-;/m1./s1

Synthetic route

methanol (67-56-1) + sodium α-d-glucoheptonatehydrate (13007-85-7) + 2,2-dimethoxy-propane (77-76-9) → methyl 2,3:4,5:6,7-tri-O-isopropylidene-D-glycero-D-gulo-heptonate (1595285-44-1)

Conditions	Yield
With hydrogenchloride at 0℃; for 1h; Temperature; Reflux; Large scale;	85%

sodium α-d-glucoheptonatehydrate (13007-85-7) + 2,2-dimethoxy-propane (77-76-9) → methyl 2,3:4,5:6,7-tri-O-isopropylidene-D-glycero-D-gulo-heptonate (1595285-44-1)

Conditions	Yield
With hydrogenchloride In methanol; water for 1h; Reflux;	54%

sodium α-d-glucoheptonatehydrate (13007-85-7) + 2,2-dimethoxy-propane (77-76-9) → C22H40O8

Conditions	Yield
With hydrogenchloride Reflux;	54%

sodium α-d-glucoheptonatehydrate (13007-85-7) → 2,3:4,5-di-O-isopropylidene-D-glycero-D-gulo-heptitol

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / water; methanol / 1 h / Reflux 2: sulfuric acid / water; methanol / 4.25 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -40 °C / Reflux View Scheme
Multi-step reaction with 3 steps 1: hydrogenchloride / 1 h / 0 °C / Reflux; Large scale 2: toluene-4-sulfonic acid / methanol / 4 h / -10 °C / Large scale 3: sodium tetrahydroborate / tetrahydrofuran / 5 h / 0 °C / Large scale View Scheme

sodium α-d-glucoheptonatehydrate (13007-85-7) → 2,3:4,5-di-O-isopropylidene-L-glucitol

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / water; methanol / 1 h / Reflux 2: sulfuric acid / water; methanol / 4.25 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -40 °C / Reflux 4: SiO2-supported NaIO4 / dichloromethane / 0.5 h View Scheme

sodium α-d-glucoheptonatehydrate (13007-85-7) → L-glucose (921-60-8)

Conditions	Yield
Multi-step reaction with 5 steps 1: hydrogenchloride / water; methanol / 1 h / Reflux 2: sulfuric acid / water; methanol / 4.25 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -40 °C / Reflux 4: SiO2-supported NaIO4 / dichloromethane / 0.5 h 5: Dowex® / water / 24 h View Scheme

sodium α-d-glucoheptonatehydrate (13007-85-7) → methyl 2,3:4,5-di-O-isopropylidene-L-glucuronate (1595285-45-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / water; methanol / 1 h / Reflux 2: sulfuric acid / water; methanol / 4.25 h / 20 °C 3: SiO2-supported NaIO4 / dichloromethane / 0.5 h / 20 °C View Scheme

sodium α-d-glucoheptonatehydrate (13007-85-7) → methyl 2,3:4,5-di-O-isopropylidene-D-glycero-D-gulo-heptonate (1595285-46-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / water; methanol / 1 h / Reflux 2: sulfuric acid / water; methanol / 4.25 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / 1 h / 0 °C / Reflux; Large scale 2: toluene-4-sulfonic acid / methanol / 4 h / -10 °C / Large scale View Scheme

(199)Re-perrhenate ion + sodium α-d-glucoheptonatehydrate (13007-85-7) → C14H24O19Re(1-)

Conditions	Yield
With tin(ll) chloride In acetic acid at 20℃; for 0.5h; pH=2.5 - 7;

sodium α-d-glucoheptonatehydrate (13007-85-7) → (2S,3R,4S,5S)-6-hydroxy-2,3:4,5-bis(isopropylenedioxy)hexanal

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / 1 h / 0 °C / Reflux; Large scale 2: toluene-4-sulfonic acid / methanol / 4 h / -10 °C / Large scale 3: sodium tetrahydroborate / tetrahydrofuran / 5 h / 0 °C / Large scale 4: sodium periodate; silica gel / dichloromethane / 1 h / Large scale View Scheme

sodium α-d-glucoheptonatehydrate (13007-85-7) → L-(-)-glucose (54-17-1, 492-61-5, 492-62-6, 492-66-0, 530-25-6, 530-26-7, 530-27-8, 530-28-9, 552-76-1, 579-36-2, 643-69-6, 655-45-8, 2280-44-6, 3646-73-9, 7282-78-2, 7282-79-3, 7282-80-6, 7282-81-7, 7282-82-8, 7283-02-5, 7283-08-1, 7283-09-2, 7283-10-5, 7283-11-6, 7296-15-3, 7296-64-2, 7322-31-8, 10257-28-0, 12772-65-5, 12773-29-4, 12773-31-8, 12773-32-9, 12773-33-0, 12773-34-1, 19982-85-5, 28538-24-1, 32445-46-8, 32445-47-9, 32445-51-5, 32445-52-6, 34685-56-8, 34685-57-9, 35810-56-1, 39281-65-7, 39281-66-8, 39281-67-9, 39281-68-0, 39281-69-1, 39392-61-5, 39392-62-6, 39392-63-7, 39392-65-9, 39392-66-0, 39392-69-3, 40825-84-1, 40825-86-3, 40825-87-4, 40825-89-6, 42752-07-8, 42789-83-3, 46032-76-2, 54808-89-8, 66069-07-6, 120442-57-1, 120442-58-2, 120442-59-3, 120442-67-3, 131064-91-0, 131064-92-1, 131065-00-4, 131065-01-5, 131348-38-4)

Conditions	Yield
Multi-step reaction with 5 steps 1: hydrogenchloride / 1 h / 0 °C / Reflux; Large scale 2: toluene-4-sulfonic acid / methanol / 4 h / -10 °C / Large scale 3: sodium tetrahydroborate / tetrahydrofuran / 5 h / 0 °C / Large scale 4: sodium periodate; silica gel / dichloromethane / 1 h / Large scale 5: Tween / water / 22 h View Scheme

sodium α-d-glucoheptonatehydrate (13007-85-7) → C7H14O11(29)Si(2-)*Na(1+) + C7H12O10(29)Si(2-)*Na(1+) + C7H12O10(29)Si(2-)*Na(1+) + C7H10O9(29)Si(2-)*Na(1+)

Conditions	Yield
With silica; sodium hydroxide In water-d2 pH=12.3;

Downstream Products

• 921-60-8 L-glucose