1300746-82-0Relevant academic research and scientific papers
6-SHOGAOL DERIVATIVES AND ACTIVITIES THEREOF
-
Paragraph 0180; 0184, (2018/10/19)
Derivatives of 6-shogaol are described herein. Also described herein are methods of preparing the derivatives, as well as methods of using the derivatives to activate Nrf2 and to treat diseases associated with inflammation and/or oxidative stress.
FLUOROALKYLATION METHODS AND REAGENTS
-
Page/Page column 7; 32, (2012/03/11)
A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.
A broadly applicable copper reagent for trifluoromethylations and perfluoroalkylations of aryl iodides and bromides
Morimoto, Hiroyuki,Tsubogo, Tetsu,Litvinas, Nichole D.,Hartwig, John F.
supporting information; experimental part, p. 3793 - 3798 (2011/05/15)
(Chemical Presented) Well compatible: The trifluoromethylations and perfluoroalkylations of aryl iodides and some aryl bromides with trifluoromethyl and perfluoroalkylcopper(I) phenanthroline complexes occur with broad scope at 25-50 8C (see scheme). The trifluoromethyl complex is prepared from inexpensive reagents and can be used in situ or isolated. The reactions tolerate a range of substituents and also occur with heteroaromatic systems.
