486994-14-3

Upstream product

• 5438-36-8 5-iodovaniline 
• 881-68-5 vanillin acetate 
• 108-24-7 acetic anhydride 
• 121-33-5 vanillin 
• 75-36-5 acetyl chloride 

Downstream Products

• 194342-88-6 4-Acetoxy-3-iodo-5-methoxy-benzoic acid 
• 670749-39-0 1-(3-methoxy-4-hydroxy-5-iodophenyl)-prop-2-en-1-ol 
• 1300746-82-0 4-formyl-2-methoxy-6-(trifluoromethyl)phenyl acetate 
• 358734-84-6 4-(carbamothioylhydrazinylidene)methyl-6-methoxy-2-iodophenyl acetate 
• 1449203-92-2 N-[5-(4-hydroxy-5-methoxy-3-iodophenyl)-1,3,4-thiadiazole-2-yl] nonanamide 
• 1449203-94-4 N-[5-(4-hydroxy-5-methoxy-3-iodophenyl)-1,3,4-thiadiazole-2-yl]-octanamide 
• 1449203-96-6 N-[5-(4-hydroxy-5-methoxy-3-iodophenyl)-1,3,4-thiadiazole-2-yl] heptanamide 
• 1449203-98-8 N-[5-(4-hydroxy-5-methoxy-3-iodophenyl)-1,3,4-thiadiazole-2-yl] hexanamide 
• 1449203-90-0 2-amino-5-(4-hydroxy-3-iodo-5-methoxyphenyl)-1,3,4-thiadiazole 
• 185416-59-5 4-hydroxy-5-iodo-3-methoxy-2-nitrobenzaldehyde 

Relevant academic research and scientific papers

TRPV-1 RECEPTOR ANTAGONIST COMPOUND DERIVED FROM 1,3,4-THIADIAZOLE ALKYLAMIDES AND CHALCONES

This technology encompasses compounds derived from 1, 3, 4-thiadiazole alkylamides and chalcone, which inhibit the activation of the TRPV-1 receptor using capsaicin and temperature. Also disclosed is the use of these compounds in the treatment of diseases with TRPV-1 overexpression, such as chronic pain.

Design, synthesis and cytotoxic activity evaluation of new aminosubstituted benzofurans

A number of new aminosubstituted benzofuran analogues have been prepared and their cytotoxic/cytostatic activity was investigated against five human tumor cell lines (MCF-7, SKBR3, SKOV3, HCT-116 and HeLa). Certain compounds showed noticeable tumor cell growth inhibition, indicative of possible structure-Activity relationships.

Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazoleheterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists

4-hydroxy-3-methoxybenzaldehyde was used as starting material to obtain a number of 1, 3, 4-thiadiazole alkylamide derivatives. The pharmacological properties of these conformationally restricted capsaicin analogues were evaluated on HEK-293T cells transiently expressing TRPV1 receptor. By means of a highthroughput calcium imaging assay we find that 1, 3, 4-thiadiazoles (compounds 8-15) act as potent antagonists of the capsaicin receptor, inhibiting both, the capsaicin- and temperature-dependent activation. Docking studies suggested a different binding orientation on the vanilloid binding site when compared with capsaicin analogues, such as 5-iodononivamide. Overall, our studies suggest that 1, 3, 4-thiadiazoles interact with capsaicin 's binding region of the receptor, although using a different set of interactions within the vanilloid binding pocket.

BENZO(b)FURAN DIMERS

Benzo[b]furan dimers and processes for their preparation are provided. The invention provides a synthetic process for the preparation of benzo[b]furan dimer using mild reaction conditions, which provides a high substituent tolerance and is appropriate for

Aliphatic acetylenic homocoupling catalyzed by a novel combination of AgOTs-CuCl2-TMEDA and its application for the solid-phase synthesis of bis-benzo[b]furan-linked 1,3-diynes

(Matrix presented) A novel catalytic system of AgOTs-CuCl 2-TMEDA is described for the homocoupling of aliphatic acetylenes on solid support. It is the first observation that AgI's activating triple bond could facilitate CuII/s

Synthesis of (±)-trans-2-[3-methoxy-4-(4 chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran

The synthesis of (± )-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl) methylphenyl]-5-(3,4,5-trimethoxyphenyl) tetrahydrofuran from commercially available vanillin acetate and 3,4,5-trimethoxy benzaldehyde is reported.