130089-93-9Relevant academic research and scientific papers
Condensed Thiazoles, II: Synthesis of 7-Substituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents
Habib,Rida,Badawey,Fahmy
, p. 1209 - 1214 (2007/10/03)
Some 3-substituted 2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-ones(2a, b; 4) have been synthesized and converted to their 7-chloro (3, 5), 7-diethanolamino (6a, b), 7-bis(2-chloroethyl)amino (7), 7-azido (8), 7-amino (9), 7-hydrazino (10), 7-mercapto (11a, b), and 7-methylthio (12) derivatives. These compounds were evaluated for their in vitro antimicrobial, anti-HIV, and anticancer activities.
Cyclizations of Cyanothioacetamide in the Presence of Sulphur
Gewald, K.,Schindler, R.
, p. 223 - 228 (2007/10/02)
Cyanothioacetoamide 1 reacts with sulphur in the presence of triethylamine to form the 2,5-diamino-thiophene derivative 3 and in the presence of sodium ethoxide the 1,4-dihydropyridine derivative 2, respectively. 3 easily undergoes ring opening to yield the butadiene derivative 6.Catalyzed by amine from 1, cyclic ketones, and sulphur the 2-spiropyrimidine-4-thiones> 8 arise.Analogously to other cyanoacetic acid derivatives 1 react with sulphur and isothiocyanates to form the 4-amino-Δ4-thiazoline-2-thiones 9 and with sulphur and carbon disulfide to yield the 5-amino-1,2-dithiol-3-thione derivative 12.Among the o-amino-thiocarboxamides 3, 9, 12 the compounds 3 and 9 can be converted into the 5,6-heterocondensed pyrimidine-4-thiones 4 and 10.
