82013-39-6

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 103-72-0 phenyl isothiocyanate 
• 13251-19-9 4-amino-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carbonitrile 

Downstream Products

• 130089-93-9 3-phenyl-7-methylthiothiazolo<4,5-d>pyrimidine-2(3H)-thione 
• 130089-91-7 3-Phenyl-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dithione 

Relevant academic research and scientific papers

On the Chemistry of 4-Amino-thiazoline-2-thiones II

6-Amino-thiazoloisothiazole derivatives 4 are obtained by addition of hydrogen sulfide to the 4-Amino-thiazoline-5-carbonitrile 2 followed by cyclooxidation of the intermediate thioamides 3.In the presence of sodium sulfite the hydrolysis of the 4-

Cyclizations of Cyanothioacetamide in the Presence of Sulphur

Cyanothioacetoamide 1 reacts with sulphur in the presence of triethylamine to form the 2,5-diamino-thiophene derivative 3 and in the presence of sodium ethoxide the 1,4-dihydropyridine derivative 2, respectively. 3 easily undergoes ring opening to yield the butadiene derivative 6.Catalyzed by amine from 1, cyclic ketones, and sulphur the 2-spiropyrimidine-4-thiones> 8 arise.Analogously to other cyanoacetic acid derivatives 1 react with sulphur and isothiocyanates to form the 4-amino-Δ4-thiazoline-2-thiones 9 and with sulphur and carbon disulfide to yield the 5-amino-1,2-dithiol-3-thione derivative 12.Among the o-amino-thiocarboxamides 3, 9, 12 the compounds 3 and 9 can be converted into the 5,6-heterocondensed pyrimidine-4-thiones 4 and 10.