130089-91-7Relevant academic research and scientific papers
Enaminonitrile in Heterocyclic Synthesis: Synthesis of Thiazolopyridine and Thiazolopyrimidine Derivatives
Elkholy, Y. M.,Elassar, A. A.
, p. 67 - 76 (2007/10/03)
Ammonium N-phenyldithiocarbamate reacted with bromomalononitrile and α-chloroacetylacetone to afford thiazole derivatives 3a, b.Compound 3a reacted with benzylidenemalononitrile, malononitrile, phenylisothiocyanate, benzoylisothiocyanate, trichloroacetonitrile, formamide, carbon disulphide and triethylorthoformate to afford thiazolopyridine derivatives 6, 9 and thiazolopyrimidine derivatives 13, 16, 18, 19, 20 and 21.Most of the synthesized products show high fungicidal and bactericidal activities.
Cyclizations of Cyanothioacetamide in the Presence of Sulphur
Gewald, K.,Schindler, R.
, p. 223 - 228 (2007/10/02)
Cyanothioacetoamide 1 reacts with sulphur in the presence of triethylamine to form the 2,5-diamino-thiophene derivative 3 and in the presence of sodium ethoxide the 1,4-dihydropyridine derivative 2, respectively. 3 easily undergoes ring opening to yield the butadiene derivative 6.Catalyzed by amine from 1, cyclic ketones, and sulphur the 2-spiropyrimidine-4-thiones> 8 arise.Analogously to other cyanoacetic acid derivatives 1 react with sulphur and isothiocyanates to form the 4-amino-Δ4-thiazoline-2-thiones 9 and with sulphur and carbon disulfide to yield the 5-amino-1,2-dithiol-3-thione derivative 12.Among the o-amino-thiocarboxamides 3, 9, 12 the compounds 3 and 9 can be converted into the 5,6-heterocondensed pyrimidine-4-thiones 4 and 10.
