130089-98-4 Usage
Description
NQ301 is a compound with antiplatelet properties, which makes it a potential antithrombotic agent. It has been shown to significantly inhibit the aggregation of washed human platelets induced by various stimuli, such as collagen, thrombin, arachidonic acid, thapsigargin, and calcium ionophore A23187.
Uses
Used in Pharmaceutical Industry:
NQ301 is used as an antithrombotic agent for its ability to inhibit platelet aggregation. This property makes it a promising candidate for the development of treatments aimed at preventing blood clot formation, which can lead to conditions such as stroke, heart attack, and deep vein thrombosis.
NQ301 is used as a research tool for studying the mechanisms underlying platelet aggregation and thrombus formation. Its ability to inhibit platelet aggregation induced by various stimuli can help researchers better understand the complex processes involved in blood clotting and identify potential targets for therapeutic intervention.
Biochem/physiol Actions
NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.
Check Digit Verification of cas no
The CAS Registry Mumber 130089-98-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,0,8 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 130089-98:
(8*1)+(7*3)+(6*0)+(5*0)+(4*8)+(3*9)+(2*9)+(1*8)=114
114 % 10 = 4
So 130089-98-4 is a valid CAS Registry Number.
130089-98-4Relevant articles and documents
Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives
Prachayasittikul, Veda,Pingaew, Ratchanok,Worachartcheewan, Apilak,Nantasenamat, Chanin,Prachayasittikul, Supaluk,Ruchirawat, Somsak,Prachayasittikul, Virapong
, p. 247 - 263 (2014/08/05)
A series of 2-substituted amino-3-chloro-1,4-naphthoquinone derivatives (3-12) were synthesized as anticancer agents and tested against four cancer cell lines including HepG2, HuCCA-1, A549 and MOLT-3. The most potent cytotoxic activity against the HepG2,
Diamine derivatives of quinone and uses thereof
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Page/Page column 12, (2010/02/10)
Diamine derivatives of quinones, and related compounds, including salts thereof, that modulate the levels of gene expression in cellular systems, such as cancer cells, are disclosed, along with methods for preparing such compounds and derivatives, as well as pharmaceutical compositions containing these compounds and derivatives as active ingredients. Methods of using these as compounds and derivatives as therapeutic agents are also described.
