13012-66-3 Usage
Chemical class
Belongs to the class of phenothiazines, a group of chemical compounds that have various applications in the pharmaceutical industry.
Mechanism of action
Works by blocking dopamine receptors in the brain, which helps to alleviate symptoms of schizophrenia, bipolar disorder, and nausea and vomiting.
Salt form
The hydrochloride salt form of the compound makes it suitable for use in oral and injectable formulations for therapeutic purposes.
Medical uses
Used as an antipsychotic and antiemetic medication in the pharmaceutical industry.
Side effects
May include drowsiness, dizziness, and dry mouth.
Precautions
Should be used with caution in patients with certain pre-existing medical conditions or concurrent use of other medications.
Dosage forms
AS-139 is available in oral and injectable formulations for therapeutic purposes.
Target receptors
Specifically targets dopamine receptors in the brain, which play a role in the regulation of mood, motivation, and cognition.
Chemical structure
The chemical structure of AS-139 includes a phenothiazine ring, an alpha-diethylaminopropionyl group, and a hydrochloride salt.
Research and development
AS-139 is a compound that has been studied for its potential therapeutic effects in various psychiatric and gastrointestinal disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 13012-66-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,1 and 2 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13012-66:
(7*1)+(6*3)+(5*0)+(4*1)+(3*2)+(2*6)+(1*6)=53
53 % 10 = 3
So 13012-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H22N2OS/c1-3-20(4-2)14-13-19(22)21-15-9-5-7-11-17(15)23-18-12-8-6-10-16(18)21/h5-12H,3-4,13-14H2,1-2H3
13012-66-3Relevant articles and documents
Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase
Elsinghorst, Paul W.,González Tanarro, Camino M.,Gütschow, Michael
, p. 7540 - 7544 (2007/10/03)
Two series of novel heterobivalent tacrine derivatives were synthesized. A trimethoxy substituted benzene was linked to the tacrine moiety by a hydrazide-based linker. The compounds were evaluated as cholinesterase inhibitors, and trimethoxybenzoic acid derivatives with 11- or 12-atom spacers were the most potent inhibitors of human acetylcholinesterase. The inhibitors showed a surprising selectivity toward human butyrylcholinesterase, where several trimethoxyphenylpropionic acid derivatives had IC50 values less than 250 pM.
