130130-81-3

Basic information

• Product Name: 4,4,4-trifluorobut-2-enoic acid
• CAS NO: 130130-81-3
• Molecular Weight: 140.062
• Mol File: 130130-81-3.mol

Chemical Properties

• CAS DataBase Reference: 4,4,4-trifluorobut-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-trifluorobut-2-enoic acid(130130-81-3)
• EPA Substance Registry System: 4,4,4-trifluorobut-2-enoic acid(130130-81-3)

Safety Data

• Hazardous Substances Data: 130130-81-3(Hazardous Substances Data)

Upstream product

• 86884-21-1 rac-4,4,4-trifluoro-3-hydroxybutanoic acid 
• 407-58-9 1,1,1-trichloro-4,4,4-trifluoro-but-2t-ene 
• 7664-93-9 sulfuric acid 
• 400-40-8 2-bromo-4,4,4-trichloro-1,1,1-trifluoro-butane 
• 25597-16-4 ethyl 4,4,4-trifluorobut-2-enoate 
• 6737-19-5 β-trifluoromethyl-β-propiolactone 

Downstream Products

• 25597-16-4 ethyl 4,4,4-trifluorocrotonate 
• 453-32-7 3-Amino-4,4,4-trifluorbutyramid 
• 1172603-97-2 4,4,4-trifluoro-N-methoxy-N-methylbut-2-enamide 
• 1408236-63-4 4,4,4-trifluoro-1,3-bis(4-trifluoromethoxyphenyl)butan-1-one 
• 1408236-64-5 4,4,4-trifluoro-1,3-bis(4-fluorophenyl)butan-1-one 
• 1408236-65-6 4,4,4-trifluoro-1,3-bis(4-chlorophenyl)butan-1-one 
• 1408236-66-7 4,4,4-trifluoro-1,3-bis(4-bromophenyl)butan-1-one 
• 1408236-67-8 4,4,4-trifluoro-1,3-bis(3-hydroxy-4-methylphenyl)butan-1-one 
• 1408236-68-9 4,4,4-trifluoro-1,3-bis(2-hydroxy-5-methylphenyl)butan-1-one 
• 78622-55-6 (E)-1-(3,3,3-trifluoroprop-1-enyl)-4-methoxybenzene 
• 851371-02-3 4,4,4-trifluoro-3-(4-methoxy-phenylsulfanyl)-butyric acid 
• 130130-82-4 (Z)-tert-butyl 4,4,4-trifluorocrotonate 

Relevant articles and documents

PRODUCTION METHOD OF FLUORINE-CONTAINING UNSATURATED CARBOXYLIC ACID

PROBLEM TO BE SOLVED: To provide a production method of a compound of formula (4), that is, a fluorine-containing unsaturated carboxylic acid, which is industrially preferable, economical, and environmentally friendly. SOLUTION: A production method of a compound of formula (4) includes subjecting a compound of formula (3) to a reaction in the presence of a base (here Rf is a 1-4C perfluoroalkyl). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPO&INPIT

BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

The effect of fluoromethyl groups on the diastereoselectivity in the electrophilic alkylation

The effect of fluoromethyl groups on the diastereoselectivity in the electrophilic alkylation is described. In particular, the electrophilic alkylation of enolates with a trifluoromethyl group was proceeded with highly diastereofacial selectivity based on the steric and/or electrostatic effect of substituent with strong electron withdrawing.