130130-82-4Relevant academic research and scientific papers
Stereospecific Synthesis of Racemic cis- and trans-6-Trifluoromethylshikimic Acids
Leroy, Jacques,Fischer, Nathalie,Wakselman, Claude
, p. 1281 - 1287 (1990)
Two 'unnatural' derivatives of shikimic acids, cis- and trans-6-trifluoromethylshikimic acid, have been synthesized in their racemic forms via the base-promoted opening of furan Diels-Alder adducts bearing a CF3 group.The relative stereochemistry of the trans-diastereoisomer has been confirmed by an X-ray analysis of its t-butyl ester.
IMPROVED SYNTHESIS OF 3-(TRIFLUOROMETHYL)PYRROLE
Leroy, J.
, p. 61 - 70 (2007/10/02)
This paper describes a synthesis of 3-(trifluoromethyl)pyrrole from t-butyl (E)-4,4,4-trifluorobutenoate and tosylmethylisocyanide via decarboxylation in 45percent yield of 4-(trifluoromethyl)pyrrole-3-carboxylic acid over barium-promoted copper chromite in quinoline.
