1301684-89-8

Upstream product

• 1301684-83-2 tert-butyl (2S,3R)-2-(tert-butyldimethylsilyloxy)-4-oxopentan-3-ylcarbamate 
• 1301684-85-4 (3R,4R,5S)-ethyl 4-(tert-butoxycarbonylamino)-5-(tertbutyldimethylsilyloxy)-3-hydroxy-3-methylhexanoate 
• 1301684-86-5 tert-butyl (2S,3R,4R)-4-hydroxy-2,4-dimethyl-6-oxotetrahydro-2H-pyran-3-ylcarbamate 
• 98-09-9 benzenesulfonyl chloride 

Relevant academic research and scientific papers

Asymmetric synthesis of 2,4,6-trideoxy-4-(dimethylamino)-3-C-methyl-l- lyxohexopyranose (Lemonose)

l-Lemonose, the glycosidic part of (-)-lemonomycin, has been synthesized in ten steps with 18% overall yield from d-threonine. The key steps are a double, highly diastereoselective Grignard addition to a Weinreb amide and a chemoselective oxidation of a primary alcohol in the presence of a secondary alcohol, a tertiary alcohol and a tertiary amine, leading directly to the lactol. Georg Thieme Verlag Stuttgart New York.