1301740-73-7Relevant academic research and scientific papers
Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
Koriyama, Yuji,Hori, Akihiro,Ito, Hisanori,Yonezawa, Shuji,Baba, Yoshiyasu,Tanimoto, Norihiko,Ueno, Tatsuhiko,Yamamoto, Shiho,Yamamoto, Takahiko,Asada, Naoya,Morimoto, Kenji,Einaru, Shunsuke,Sakai, Katsunori,Kanazu, Takushi,Matsuda, Akihiro,Yamaguchi, Yoshitaka,Oguma, Takuya,Timmers, Maarten,Tritsmans, Luc,Kusakabe, Ken-Ichi,Kato, Akira,Sakaguchi, Gaku
, p. 1873 - 1888 (2021/03/01)
Accumulation of amyloid β peptides (Aβ) is thought to be one of the causal factors of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting protease for Aβ production, and therefore
AMINOTHIAZINE OR AMINOOXAZINE DERIVATIVE HAVING AMINO LINKER
-
Page/Page column 30, (2012/09/25)
The present invention provide a medicament for treating the diseases induced by production, secretion or deposition of amyloid-2 proteins, for example, a compound of the following formula (I) wherein R1, R2a, R2b, R3, R4, R5, X, L1, L2, A, ring B and the dotted line are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.
SUBSTITUTED AMINOTHIAZINE DERIVATIVE
-
Page/Page column 65, (2012/10/08)
The present invention relates to an agent for treating or preventing disease induced by production, secretion and/or deposition of amyloid β protein, for example, a compound of formula (I), wherein, R1, R2a, R2b R3, R4a, R4b, ring A, and dashed line are described in this specification, its pharmaceutically acceptable salt or a solvate thereof.
