1301760-11-1

Basic information

• Product Name: (2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride
• Synonyms: (2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride
• CAS NO: 1301760-11-1
• Molecular Formula: C₁₅H₂₅NO₅
• Molecular Weight: 299.3627
• Mol File: 1301760-11-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride(1301760-11-1)
• EPA Substance Registry System: (2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride(1301760-11-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1301760-11-1(Hazardous Substances Data)

Usage

General Description

The chemical "(2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride" is a compound with a complex molecular structure. It consists of a tetrahydro-1H-pyrrole ring with a carboxylic acid moiety and a 2-methylbutanoic anhydride group. The presence of a tert-Butoxycarbonyl (Boc) protecting group indicates its potential use in peptide synthesis or as a precursor in organic chemistry. The compound's stereochemistry is designated as (2R), indicating a specific configuration at the carbon center. Overall, the chemical is likely to have applications in organic synthesis, pharmaceutical research, or as a building block for the production of other compounds.

Upstream product

• 344-25-2 D-Prolin 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 108-12-3 isopentanoyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 201039-13-6 (R)-2-cyanomethyl pyrrolidine-1-carboxylic acid, tert-butyl ester 

Relevant articles and documents

Synthesis and biological evaluation of potential 5-HT7 receptor PET radiotracers

Brain serotonin 7 receptor (5-HT7) is involved in several mood disorders and drug candidates targeting this subtype are currently in development. Positron emission tomography (PET) is a molecular imaging modality offering great promise for accelerating the process from preclinical discovery to clinical phases. As no PET radiopharmaceutical has yet been used successfully to study the 5-HT7 receptor in vivo, our objective is to develop the first 5-HT7 fluorine-18 labeled radiotracer. Four structural analogs of SB269970, a specific 5-HT7 receptor antagonist, divided in FP3 series and FPMP series were synthesized. Their antagonist effects were investigated by cellular functional assay. Nitro-precursors of these analogs were radiolabeled via a [18F-]nucleophilic substitution and in vitro autoradiographies were performed in rat brain. Chemical and radiochemical purities of fluorine radiotracers were >99% with specific activities in 40-129 GBq/μmole range. The four derivates presented antagonism potencies toward 5-HT7 receptors (pKB) between 7.8 and 8.8. The four PET radiotracers had suitable characteristic for 5-HT7 receptor probing in vitro even if the FP3 series seemed to be more specific for this receptor. These results encourage us to pursue in vivo studies.