130182-00-2

Usage

Class

Coumarins

Attached Groups

Phenyl group at 4th position, Ethyl group at 6th position

Functional Group

Hydroxyl group at 7th position

Properties

Antioxidant
Anti-inflammatory
Anti-cancer

Potential Therapeutic Applications

Treatment of various diseases

Industrial Uses

Food industry (flavoring)
Cosmetic industry (fragrance)

Upstream product

• 2896-60-8 4-ethyl-1,3-benzenediol 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 1033002-54-8 6-ethyl-7-hydroxy-2-oxo-4-phenyl-2H-chromen-8-carbaldehyde 
• 854642-62-9 8-acetyl-6-ethyl-7-hydroxy-4-phenyl-2H-chromen-2-one 
• 405903-67-5 6-ethyl-7-acetoxy-4-phenylchromen-2-one 
• 178754-68-2 6-Ethyl-7-methoxy-4-phenyl-chromen-2-one 

Relevant academic research and scientific papers

A new method for the facile synthesis of hydroxylated flavones by using allyl protection

The iodine-induced oxidative cyclization of 2′-hydroxychalcones provides a simple, highly efficient approach to various hydroxy flavones and analogues. This process is run under mild conditions, tolerates various functional groups, and provides hydroxy flavones in good to excellent yield. The allyl-protected acetophenones and benzaldehydes were smoothly deallylated under similar conditions.

CONDENSATION OF ETHYL ACETOACETATE AND ETHYL BENZOYLACETATE WITH 4-ALKYLRESORCINOLS IN THE PRESENCE OF BF3 ETHER COMPLEX

The reactions of ethyl acetoacetate and ethyl benzoylacetate with 4-alkylresorcinols catalyzed by BF3 ether complex, give new 6-alkyl-7-hydroxy-4-methyl- and 6-alkyl-7-hydroxy-4-phenyl-coumarins.A mechanism of coumarin formation is suggested.