130217-49-1Relevant academic research and scientific papers
NOVEL ANILINE DERIVATIVES AND USE THEREOF
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Paragraph 0098-0101, (2014/05/25)
Aniline derivatives for anticancer treatment including a compound of the Formula 1, or a derivative thereof, as an active ingredient,
Design, synthesis and molecular docking of substituted 3-hydrazinyl-3-oxo-propanamides as anti-tubercular agents
Naqvi, Arshi,Malasoni, Richa,Srivastava, Akansha,Pandey, Rishi Ranjan,Dwivedi, Anil Kumar
supporting information, p. 5181 - 5184 (2014/12/11)
Based on the anti-mycobacterial activity of various acid hydrazides, a series of substituted 3-hydrazinyl-3-oxo-propanamides has been designed. The target compounds have been synthesized from diethylmalonate using substituted amines and hydrazine hydrate
NOVEL ANILINE DERIVATIVES AND USE THEREOF
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Paragraph 169-174, (2013/03/26)
The present invention relates a novel aniline derivatives for anticancer and more particularly, it relates a novel aniline derivatives for anticancer comprising compound of the Formula 1 or a derivative thereof as an active ingredient. A compound of the present invention inhibits AIMP2-DX2 which is novel anticancer target and induces apoptosis of cancer cells, thereby being effective in preventing and treating cancer. Therefore, a novel aniline derivatives of the present invention can be used for preventing and treating cancer.
Ethyl malonate amides: A diketo acid offspring fragment for HIV integrase inhibition
Serafin, Katarzyna,Mazur, Pawel,Bak, Andrzej,Laine, Elodie,Tchertanov, Luba,Mouscadet, Jean-Franois,Polanski, Jaroslaw
experimental part, p. 5000 - 5005 (2011/10/04)
While searching for new HIV integrase inhibitors we discovered that some ethyl malonate amides (EMA) are active against this enzyme. Surprisingly, the main function can only very rarely be found among the reported drug candidates. We synthesised a series
Ethyl Esters of Malonanilic Acids. Synthesis and Pyrolysis
Ukrainets, Igor V.,Bezugly, Peter A.,Treskach, Vladimir I.,Taran, Svetlana G.,Gorokhova, Olga V.
, p. 10331 - 10338 (2007/10/02)
The pyrolysis under 170-220 deg C or boiling in DMF of malonanilic acids ethyl esters (2) is accompanied by formation of malonic acids symmetric dianilides (7) with high yields.A possible mechanism for this transformation has been suggested.
ACYLATION OF ORTHO(PARA)-SUBSTITUTED AROMATIC AMINES BY MALONIC ACID DERIVATIVES
Bezuglyi, P. A.,Treskach, V. I.,Ukrainets, I. V.,Grinenko, V. V.,Bevz, N. Yu.
, p. 1233 - 1236 (2007/10/02)
The reaction of diethyl malonate with primary ortho(para)-substituted arylamines leads to the formation of ethyl malonanilates or symmetrical malonanilides, depending on the temperature and on the nucleophilic characteristics of the amines.
