130226-18-5

Basic information

• Product Name: Win 61834
• Synonyms: 3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]benzonitrile;3,5-DiMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]-benzonitrile;Win 61834
• CAS NO: 130226-18-5
• Molecular Formula: C₁₆H₁₈N₂O₂
• Molecular Weight: 270.32632
• Product Categories: Pharmaceuticals;Anti-virals, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals;Anti-virals;Heterocycles;Intermediates & Fine Chemicals
• Mol File: 130226-18-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Win 61834(CAS DataBase Reference)
• NIST Chemistry Reference: Win 61834(130226-18-5)
• EPA Substance Registry System: Win 61834(130226-18-5)

Safety Data

• Hazardous Substances Data: 130226-18-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate in the preparation of antiviral Pleconaril (P580350).

Upstream product

• 23382-09-4 silicon dioxide hydrate 
• 4198-90-7 3,5-dimethyl-4-hydroxybenzonitrile 
• 130800-76-9 3-(3-methylisoxazol-5-yl)propyl chloride 

Downstream Products

• 152775-44-5 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole 
• 153168-13-9 acetic acid, <3-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-1,2,4-oxadiazol-5-yl>methyl ester 
• 153168-16-2 5-{3-[2,6-Dimethyl-4-(5-trichloromethyl-1,2,4-oxadiazol-3-yl)-phenoxy]propyl}-3-methylisoxazole 
• 153168-12-8 5-{3-[2,6-Dimethyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-3-methylisoxazole 
• 156787-18-7 5-chloro-3-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-1,2,4-oxadiazole 

Relevant articles and documents

1,2,4-OXADIAZOLYL-PHENOXYALKYLISOXAZOLES AND THEIR USE AS ANTIVIRAL AGENTS

Compounds of the formula wherein: R1 is alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, alkoxyalkyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy, or cyanomethyl; Y is alkylene of 3 to 9 carbon atoms, R2 and R3 independently are hydrogen, alkyl, alkoxy, halo, cyano, trifluoromethyl and nitro; R4 is alkoxy, hydroxy, halomethyl, dihalomethyl, trihalomethyl, dihaloethyl, cycloalkyl, heterocyclyl, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, alkanecarbonyloxyalkyl, cyano, halo, thioalkyl, alkylthioalkyl, alkylthio, thio, 2,2,2-trifluoro-ethyl, (4-methylphenyl)sulfonyloxymethyl, N=Q or CON=Q, where N=Q is amino, alkylamino or dialkylamino; R5 is hydrogen or halo or alkyl

Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity

A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the MIC80, the concentration which inhibits 80% or 12 of the serotypes tested, was determined. Homologation of the alkyl