130232-51-8Relevant academic research and scientific papers
Preparation method of carboxylic ester compound
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Paragraph 0030-0031, (2021/03/30)
The invention relates to a preparation method of a carboxylic ester compound, which comprises the following steps: reacting carboxylic acid with methanol in air under the catalysis of nitrite to obtain an ester compound, the preparation method disclosed by the invention has the advantages of rich raw material sources, cheap and easily available catalyst, mild reaction conditions, simplicity and convenience in operation and the like, a series of fatty carboxylic acids can be modified with high yield, and particularly, the traditional esterification method is generally not suitable for esterification of drug molecules. By utilizing the method, a series of known drug molecules can be modified, so that a shortcut is provided for discovering new drug molecules.
Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite
Cheng, Xionglve,Jiang, Gangzhong,Li, Xingxing,Tao, Suyan,Wan, Xiaobing,Zhao, Yanwei,Zheng, Yonggao
supporting information, p. 2713 - 2718 (2021/06/25)
In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.
A method for preparing the fat cumaric acupoint of the c bethe method
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, (2017/10/07)
The invention discloses a method for preparing a hypolipidemic medicine ciprofibrate with p-coumaric acid. The method comprises the following specific steps: p-coumaric acid (I) is subjected to a decarboxylation reaction under the effect of an alkaline catalyst, such that p-hydroxystyrene (II) is obtained; p-hydroxystyrene (II) is subjected to a reaction with 2-haloisobutyrate under the effect of alkali, such that an etherified product (III) is obtained; under an alkaline condition, the etherified product (III) and chloroform are subjected to a cyclization reaction under the effect of a phase transfer catalyst, such that a cyclized product (IV) is obtained; the cyclized product (IV) is subjected to alcoholysis and acidification in an alkali solution; and recrystallization is carried out, such that ciprofibrate (V) is obtained. The method provided by the invention has the advantages of short synthesis process, safe operation and easy post-treatment. The method is suitable for large-scale industrialized productions, and almost has no possibility of causing accidents such as explosion. During the entire reaction process, only conventional acid, alkali and solvent are used, such that the cost is low. The solvent can be recovered and reused, such that the method is environment-friendly. With the method, the yield is improved by more than 20%.
A new method for synthesizing cyclopropanecarboxylic Bethe
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Paragraph 0055-0056; 0066-0067; 0075-0076, (2018/02/04)
The invention discloses a novel ciprofibrate synthesis method. The novel ciprofibrate synthesis method comprises the specific steps that p-hydroxy benzaldehyde (I) and malonic acid perform condensation decarboxylation reaction in the presence of an alkaline catalyst to obtain p-hydroxystyrene (II), the p-hydroxystyrene (II) reacts with 2-halogenated isobutyrate under the action of alkali to obtain an etherification product (III), the etherification product (III) and chloroform perform cyclization reaction under the alkaline condition and under the action of a phase transfer catalyst to obtain a cyclization product (IV), and the cyclization product (IV) is subjected to alcoholysis, acidification and recrystallization in an alkaline solution to obtain ciprofibrate (V). The novel ciprofibrate synthesis method comprises few synthesis steps, industrial operation is simple and convenient, the conditions are moderate and are easy to control, almost no possibility of explosion and other accidents exists, operation is safe, aftertreatment is convenient, a process is stable, large-scale industrial production is easy to achieve, only conventional acid, alkali and solvents are used in the whole reaction process, the novel ciprofibrate synthesis method is low in cost and is environmentally friendly, and the yield is improved by above 15%.
Levo-ciprofibrate
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, (2008/06/13)
Levo-ciprofibrate or a pharmaceutically acceptable salt thereof is disclosed.
Dextro-ciprofibrate
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, (2008/06/13)
Dextro-ciprofibrate or a pharmaceutically acceptable salt thereof is disclosed.
