130263-77-3Relevant articles and documents
Synthesis of Clustered Glycoside - Antigen Conjugates by Two One-Pot, Orthogonal, Chemoselective Ligation Reactions: Scope and Limitations
Grandjean, Cyrille,Gras-Masse, Helene,Melnyk, Oleg
, p. 230 - 240 (2001)
Major histocompatibility class II antigens have been bound to clustered glycosides for selective targeting of the dendritic cell mannose receptor. Di-, tetra-, and octavalent glycoside - antigen conjugates have been obtained after two, orthogonal, hydrazo
Glucose- and pH-responsive controlled release of cargo from protein-gated carbohydrate-functionalized mesoporous silica nanocontainers
Wu, Shanshan,Huang, Xuan,Du, Xuezhong
, p. 5580 - 5584 (2013)
Learning to let go: Controlled release of cargo (purple cubes) from lectin (blue squares)-gated nanopores was achieved using mannose (green loops)-functionalized mesoporous silica (see scheme). The protein nanogates could be opened either by decreasing the pH of the buffer or by adding competing glucose (yellow rings) to release the cargo from the pores. Copyright
ANTIFOLATE-CARRYING NANOPARTICLES AND THEIR USE IN MEDICINE
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Page/Page column 36-38, (2020/07/07)
The present invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: (i) at least one dilution ligand comprising a carbohydrate, glutathione or an ethylene glycol-containing moiety; and (ii) a ligand of the formula D-L1-Z-L2, wherein D comprises an antifolate drug or folic acid, L1 comprises a first linker portion comprising a C2-C12 glycol and/or C2-C12 alkyl chain, L2 comprises a second linker portion comprising a C2-C12 glycol and/or C2-C12 alkyl chain, wherein L1 and L2 may be the same or different, and wherein Z represents a carbonyl-containing group linking L1 and L2, and wherein L2 is coupled to said core, Also provided are pharmaceutical compositions comprising such nanoparticles, medical uses thereof and methods for producing the nanoparticles.
A Bifunctional Spin Label for Ligand Recognition on Surfaces
Hollas, Michael A.,Webb, Simon J.,Flitsch, Sabine L.,Fielding, Alistair J.
supporting information, p. 9449 - 9453 (2017/08/01)
In situ monitoring of biomolecular recognition, especially at surfaces, still presents a significant technical challenge. Electron paramagnetic resonance (EPR) of biomolecules spin-labeled with nitroxides can offer uniquely sensitive and selective insights into these processes, but new spin-labeling strategies are needed. The synthesis and study of a bromoacrylaldehyde spin label (BASL), which features two attachment points with orthogonal reactivity is reported. The first examples of mannose and biotin ligands coupled to aqueous carboxy-functionalized gold nanoparticles through a spin label are presented. EPR spectra were obtained for the spin-labeled ligands both free in solution and attached to nanoparticles. The labels were recognized by the mannose-binding lectin, Con A, and the biotin-binding protein avidin-peroxidase. Binding gave quantifiable changes in the EPR spectra from which binding profiles could be obtained that reflect the strength of binding in each case.
