130266-79-4

Basic information

• Product Name: 1,2-Benzisothiazol-3(2H)-one, 2-[(4-methoxyphenyl)methyl]-
• CAS NO: 130266-79-4
• Molecular Formula: C15H13NO2S
• Molecular Weight: 271.34
• Mol File: 130266-79-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,2-Benzisothiazol-3(2H)-one, 2-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisothiazol-3(2H)-one, 2-[(4-methoxyphenyl)methyl]-(130266-79-4)
• EPA Substance Registry System: 1,2-Benzisothiazol-3(2H)-one, 2-[(4-methoxyphenyl)methyl]-(130266-79-4)

Safety Data

• Hazardous Substances Data: 130266-79-4(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 54856-20-1 N-[2-(methoxycarbonyl)benzenesulfenyl]-1,2-benzisothiazolin-3-one 
• 94266-24-7 2-methoxycarbonylbenzenesulfenamide 
• 256947-56-5 ethyl 2-sulfenamoylbenzoate 
• 1442-03-1 2-methylsulfanyl-benzoyl chloride 
• 3724-10-5 2-(methylthio)benzoic acid 
• 37798-75-7 2,2′-disulfanediylbis(N-(4-methoxybenzyl)benzamide) 
• 119-80-2 2,2'-dithiobenzoic acid 
• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 2634-33-5 1,2-benzisothiazolin-3-one 
• 824-94-2 p-methoxybenzyl chloride 

Relevant articles and documents

Synthetic method 1-2 - benzisothiazol -3 -one compound (by machine translation)

The invention discloses a synthetic method of 1-2 - benzisothiazol -3 -one compound, and belongs to the field of chemical synthesis. 2 - 1-benzisothiazol 2 -one compounds are synthesized through acid chlorination, amidation and cyclization reaction by using the sulfenyl-substituted benzoic acid extracted from BIT process -3 - waste water as a starting raw material. The method disclosed by the invention has the advantages of mild reaction conditions, simple and convenient operation, strong practicability, less waste water, high product purity and the like, and is suitable for large-scale industrial production. The technical scheme provided by the invention is resource utilization and preparation 1 of wastewater extract produced in BIT production, and a feasible method is provided for the 2 -benzisothiazol -3 -one compound. (by machine translation)

1,2-BENZISOSELENAZOL-3(2H)-ONE AND 1,2-BENZISOTHIAZOL-3(2H)-ONE DERIVATIVES AS BETA-LACTAM ANTIBIOTIC ADJUVANTS

Provided herein are compositions and methods useful in the treatment of beta-lactam antibiotic resistant bacteria.

Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors

A number of 1,2-benzisothiazol-3-one derivatives were prepared through structural modification of the original compound from high-throughput screening. Some analogues (e.g., 6b, 6r, 6s and 6w) were identified as novel and potent caspase inhibitors with IC50 of nanomolar. Structure-activity relationship (SAR) studies for caspase-3 inhibition were evaluated in vitro. Molecular modeling studies provided further insight into the interaction of this class of compounds with activated caspase-3. The present small molecule caspase-3 inhibitor with novel structures different from structures of known caspase inhibitors revealed a new direction for therapeutic strategies directed against diseases involving abnormally up-regulated apoptosis.