3724-10-5

Usage

Uses

Used in Organic Synthesis:
2-(METHYLTHIO)BENZOIC ACID is used as a key intermediate for the synthesis of various organic compounds. Its ability to undergo a range of chemical reactions, such as substitution, addition, and condensation, makes it a valuable building block in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(METHYLTHIO)BENZOIC ACID serves as a crucial raw material for the development of new drugs. Its unique chemical structure allows for the design and synthesis of novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Agrochemicals:
2-(METHYLTHIO)BENZOIC ACID is utilized as an essential component in the formulation of agrochemicals, such as pesticides and herbicides. Its incorporation into these products enhances their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and improved agricultural productivity.
Used in Dye Stuffs:
In the dye and pigment industry, 2-(METHYLTHIO)BENZOIC ACID is employed as a vital intermediate for the production of various types of dyes. Its chemical properties enable the creation of dyes with specific color characteristics and improved stability, making it an indispensable component in the dye manufacturing process.

InChI:InChI=1/C8H8O2S/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3,(H,9,10)/p-1

Upstream product

• 16671-86-6 2-thiocyanatobenzoic acid 
• 512-42-5 sodium methyl sulfate 
• 17333-86-7 o-Carboxybenzenediazonium 
• 60-29-7 diethyl ether 
• 100-68-5 methyl-phenyl-thioether 
• 2399-59-9 diethylstrontium 
• 34511-03-0 diethyl-barium 
• 3704-28-7 methyl 2-(methylthio)benzoate 
• 6609-54-7 2-cyanothioanisole 
• 119-80-2 2,2'-dithiobenzoic acid 
• 5459-63-2 bis[2-(methoxycarbonyl)phenyl]disulfide 
• 3724-11-6 2-(methylthio)tropone 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 520-72-9 3-hydroxybenzothiophene 
• 130-03-0 thioindoxyl 
• 19093-34-6 2-(methylsulfinyl)benzoic acid 
• 33963-55-2 2-(methylsulfonyl)benzoic acid 
• 1442-03-1 2-methylsulfanyl-benzoyl chloride 
• 52333-80-9 2-(2-methylsulfanyl-phenyl)-oxazolo[4,5-b]pyridine 
• 492-22-8 thio-xanthene-9-one 
• 67373-13-1 2-phenylsulfanyl-benzoic acid methyl ester 
• 121451-34-1 N-(2-methylthiobenzoyl)-L-proline t-butyl ester 
• 62778-81-8 2-(Methylthio)benzoesaeure-dimethylamid 
• 25865-15-0 N-[4-(3-cyclohexyl-2-imino-imidazolidine-1-sulfonyl)-phenethyl]-2-methylsulfanyl-benzamide 
• 121451-39-6 N-(2-methylthiobenzoyl)-L-proline ethyl ester 
• 1441-97-0 2'-(methylthio)acetophenone 
• 1442-00-8 ethyl 2-(methylthio)benzoate 

Relevant academic research and scientific papers

Rearrangements in the Molecular Ion of o-(Methyl-d3-thio)benzoic acid: Comparison with o-Methoxy-d3-benzoic Acid

Hydrogen/deuterium exchange and rearrangements in the molecular ion of o-(methyl-d3-thio)benzoic acid lead to fragment ions + as well as + and m/z 106 and 107, just as in the molecular ion of o-methoxybenzoic a

Palladium-Catalyzed C-S Bond Formation as a Tool for Latent-Active Glycosylation

A high-yielding palladium-catalyzed C-S cross-coupling is presented for utilization in carbohydrate chemistry as a key transformation for attachment of a second chelating sulfur atom that allows the exploitation of a latent-active glycosylation strategy w

Photocatalytic Deoxygenation of Sulfoxides Using Visible Light: Mechanistic Investigations and Synthetic Applications

The photocatalytic deoxygenation of sulfoxides to generate sulfides facilitated by either Ir[(dF(CF3)ppy)2(dtbbpy)]PF6 or fac-Ir(ppy)3 is reported. Mechanistic studies indicate that a radical chain mechanism operates, which proceeds via a phosphoranyl radical generated from a radical/polar crossover process. Initiation of the radical chain was found to proceed via two opposing photocatalytic quenching mechanisms, offering complementary reactivity. The mild nature of the radical deoxygenation process enables the reduction of a wide range of functionalized sulfoxides, including those containing acid-sensitive groups, in typically high isolated yields.

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.

INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR

The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

Indole derivative serving as CRTH2 inhibitor

The invention discloses an indole derivative serving as a CRTH2 inhibitor shown as a formula (I) as shown in the specification or pharmaceutically acceptable salts, as well as application of the indole derivative in treatment of diseases related to the CR

DNA binding and antitumor activities of platinum(IV) and zinc(II) complexes with some S-alkyl derivatives of thiosalicylic acid

A series of complexes of platinum(IV) (C1–C5) and zinc(II) (C6–C10) with S-alkyl derivatives of thiosalicylic acid were prepared and characterized. The interactions of the complexes with calf thymus DNA were analyzed by absorption (UV–Vis) and emission spectral studies (ethidium bromide displacement studies). The cytotoxic activities of complexes C1–C10 were determined against mouse B cell lymphocytic leukemia cells (BCL1), human B-prolymphocytic leukemia (JVM-13), mouse mammary carcinoma cells (4T1), and human mammary carcinoma cells (MDA-MB-468) and compared to the activities of the free ligand precursors and cisplatin. The cytotoxicities of the platinum(IV) and zinc(II) complexes toward mouse tumor cell lines were higher compared with their effects on human tumor cell lines. The zinc(II) complex C9 showed the highest antitumor activity toward the tested human cell lines, while the platinum(IV) complex C4 exhibited the highest antitumor activity toward mouse BCL1 and 4T1 cells. Both C4 and C9 have ligands derived from S-propyl thiosalicylic acid.

Bistable Photoswitching of Hemithioindigo with Green and Red Light: Entry Point to Advanced Molecular Digital Information Processing

Photoswitches reacting to visible light instead of harmful UV irradiation are of very high interest due to the mild and broadly compatible conditions of their operation. Shifting the absorption into the red region of the electromagnetic spectrum usually comes at the cost of losing thermal stability of the metastable state—the switch switches off by itself. Only recently have photoswitches become available that combine visible light responsiveness with high bistability. However, shifting the wavelengths for bistable photoswitching beyond 600 nm is still a great challenge without involving secondary processes such as two-photon absorption or sensitization. We present a simple hemithioindigo photoswitch that can efficiently be photoisomerized using green and red light while maintaining a high thermal barrier of the metastable state. This highly sought after properties allow for selective switching in a mixture of hemithioindigo dyes. In addition, protonation can be used as second independent input altering the light response of the switch and allowing construction of advanced molecular digital information processing devices. This is demonstrated by realizing a broad variety of logical operations covering combinational and sequential logic behavior. By making use of the protonation-induced loss of thermal bistability, a high security keypad lock could be realized, which distinguishes the sequences of three different inputs and additionally erases its unlocked state after a short time.

New piperazine derivatives having anti-cancer effect, combination therapeutic effect with radiation, and anti-diabetic effect, and PPAR activity, and medical use thereof

The present invention relates to a novel piperazine derivative having an anti-cancer effect, a combination therapeutic effect with radiation, and an anti-diabetic effect, and to a medical use thereof. The piperazine derivatives are PPAR-γ ligand, and have

Copper(I)-Catalyzed Alkyl- and Arylsulfenylation of 3,4-Dihalo-2(5H)-furanones (X=Br, Cl) with Sulfoxides under Mild Conditions

An efficient copper(I)/proline sodium salt-catalyzed alkyl- and arylsulfenylation of C(sp2)–X 3,4-dihalo-2(5H)-furanone compounds with sulfoxides is described. For inexpensive C(sp2)–Cl compounds, there is also a satisfactory reactivity with the moderate yields. This transformation provides a novel approach for the utilization of sulfoxides (not only DMSO) as sulfur source at mild temperatures without the need for an anaerobic atmosphere. More importantly, both sulfoxide and proline sodium salt can play a dual role in this reaction. (Figure presented.).