130282-65-4Relevant academic research and scientific papers
Regioselective 1-O-acyl hydrolysis of peracylated glycopyranoses by mercuric chloride and mercuric oxide
Sambaiah,Fanwick,Cushman
, p. 1450 - 1452 (2001)
A convenient synthetic method for regioselective 1-O-acyl hydrolysis of peracylated glycopyranoses into tetra-O-acylgly-copyranoses using mercuric chloride and mercuric oxide in aqueous acetone is described.
Room-temperature ionic liquids enhanced green synthesis of β-glycosyl 1-ester
Cui, Yanli,Xu, Minghan,Yao, Weirong,Mao, Jianwei
, p. 51 - 54 (2015/03/04)
We herein report an efficient synthesis of β-glycosyl 1-ester in room-temperature ionic liquids (RTILs) promoted via silver salt and quaternary ammonium salt (PTC) with good or excellent yields. All products were isolated exclusively as the β-anomers. Four different RTILs, eight metal salts and four quaternary ammonium salts were screened in the glycosylation reaction. The synergistic effect of C6mim·OTf, Ag2O and tetrabutylammonium iodine gave the best results. Their promotion to the system was integral. Thorough study provided insight into the catalytic activity of ionic liquid structure, metal salts and quaternary ammonium salt to these reactions. It is worth mentioning that the yield of aliphatic compound 2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl butyrate (3l) was highly improved when using C6mim·OTf as solvent compared with the normal volatile solvents under the same catalysts. This green approach has been proved to be practical and compatible with a wide range from aliphatic to aromatic substrates.
Phyllanthoside-Phyllanthostatin Synthetic Studies. 8. Total Synthesis of (+)-Phyllanthoside. Development of the Mitsunobu Glycosyl Ester Protocol
Smith III, Amos B.,Rivero, Ralph A.,Hale, Karl J.,Vaccaro, Henry A.
, p. 2092 - 2112 (2007/10/02)
The first total syntheses of the antineoplastic glycoside (+)-phyllanthoside (1) and the parent disaccharide (-)-phyllanthose (5) have been achieved. Stereoselective Koenigs-Knorr coupling of two 6-deoxyglucose derivatives, bromide 54 and alcohol 55, generated the uncommon 1′ → 2β glycosidic linkage of (-)-phyllanthose. A stereochemically convergent Mitsunobu reaction of protected disaccharide 87 with aglycon carboxylic acid 80, prepared via asymmetric synthesis, then led to 1 of high enantiomeric purity. The Mitsunobu procedure comprises an efficient general method for stereospecific assembly of β-glycosyl esters.
