130339-72-9

Basic information

• Product Name: Benzoic acid, 3-benzoyl-, ethyl ester
• CAS NO: 130339-72-9
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Mol File: 130339-72-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-benzoyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-benzoyl-, ethyl ester(130339-72-9)
• EPA Substance Registry System: Benzoic acid, 3-benzoyl-, ethyl ester(130339-72-9)

Safety Data

• Hazardous Substances Data: 130339-72-9(Hazardous Substances Data)

Upstream product

• 24398-88-7 ethyl 3-bromobenzoate 
• 98-88-4 benzoyl chloride 
• 579-18-0 3-benzoylbenzoic acid 
• 78-39-7 Triethyl orthoacetate 
• 64-17-5 ethanol 
• 85-44-9 phthalic anhydride 
• 71-43-2 benzene 
• 93-89-0 benzoic acid ethyl ester 
• 58313-23-8 3-iodobenzoic acid methyl ester 
• 1072906-23-0 C₉H₉ClO₂Zn 

Relevant articles and documents

Erratum to: Design, characterization, computational studies and pharmacological evaluation of substituted-N′-[(1E) substituted- phenylmethylidene]benzohydrazide analogs (Medicinal Chemistry Research (2013) 22 (2755-2767) DOI:10.1007/s00044-012-0270-0)

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Palladium-phosphinous acid-catalyzed cross-coupling of aryl and acyl halides with aryl-, alkyl-, and vinylzinc reagents

(Chemical Equation Presented) Several palladium-phosphinous acids have been prepared and employed in cross-coupling reactions of aryl or acyl halides with aliphatic and aromatic organozinc reagents. The POPd7-catalyzed reaction of aryl halides, including electron-rich aryl chlorides, and arylzinc reagents was found to afford biaryls exhibiting alkoxy, alkylthio, amino, ketone, cyano, nitro, ester, and heteroaryl groups in 75-93% yield. Excellent results were obtained with sterically hindered substrates which gave di- and tri-ortho-substituted biaryls in up to 92% yield. Aryl halides also undergo POPd7-catalyzed aryl-vinyl and aryl-alkyl bond formation under mild conditions. Styrenes and alkylarenes were prepared in 79-93% yield from aryl halides and vinyl or alkylzinc reagents. The replacement of aryl halides by acyl halides provides access to ketones which were produced in up to 98% yield when POPd was used as catalyst. This approach overcomes the limited substrate scope, reduced regiocontrol, and low functional group tolerance of traditional Friedel-Crafts acylation methods.

Synthesis of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole analogues as novel antiplatelet agents

1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (28, YC-1) was selected as the lead compound for systemic structural modification. After screening for antiplatelet activity, SARs of YC-1 analogues were established. Among these potent active derivatives, co