130340-04-4

Basic information

• Product Name: trans-2-Fluoro-cyclopropanecarboxylic acid
• Synonyms: trans-2-Fluoro-cyclopropanecarboxylic acid;Trans-2-Fluoro-Cyclopropanecarboxylic Acid(WX610333);rel-((1S,2R)-2-Fluorocyclopropane-1-carboxylic acid)
• CAS NO: 130340-04-4
• Molecular Formula: C₄H₅FO₂
• Molecular Weight: 104.0797032
• Mol File: 130340-04-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 202.3±33.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.00±0.11(Predicted)
• CAS DataBase Reference: trans-2-Fluoro-cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-2-Fluoro-cyclopropanecarboxylic acid(130340-04-4)
• EPA Substance Registry System: trans-2-Fluoro-cyclopropanecarboxylic acid(130340-04-4)

Safety Data

• Hazardous Substances Data: 130340-04-4(Hazardous Substances Data)

Usage

General Description

Trans-2-Fluoro-cyclopropanecarboxylic acid is a chemical compound with the molecular formula C4H5FO2. It is a colorless, odorless solid that is typically used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. trans-2-Fluoro-cyclopropanecarboxylic acid contains a cyclopropane ring, which gives it unique chemical properties and reactivity. It is important to handle this compound with care, as it can be corrosive and harmful if ingested or inhaled. Additionally, it is important to store it in a cool, well-ventilated area away from sources of ignition and incompatible substances.

InChI:InChI=1S/C4H5FO2/c5-3-1-2(3)4(6)7/h2-3H,1H2,(H,6,7)/t2-,3-/m0/s1

Upstream product

• 152237-14-4 tert-butyl 2-fluoro-cyclopropane-1-carboxylate 
• 137081-42-6 2-chloro-2-fluorocyclopropane carboxylic acid 

Downstream Products

• 169884-67-7 (rac-(1R,2S)-2-fluorocyclopropyl)methanol 
• 127199-12-6 2-Fluoro-cyclopropanecarboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 185225-82-5 (±)-trans-2-fluorocyclopropanecarbonyl chloride 

Relevant articles and documents

PROCESS FOR PRODUCING 1,2-CIS-2-FLUOROCYCLOPROPANE-1-CARBOXYLIC ESTER COMPOUND

Provided is an industrially applicable process for producing 1,2-cis-2-fluorocyclopropane-1-carboxylic ester. A process for producing a compound represented by formula (3): [wherein R 1 represents, for example, a C1-C8 alkyl group], which process includes reacting a compound represented by formula (1) : [wherein X 1 represents a hydrogen atom, a chlorine atom, a bromine atom, or an iodine atom; X 2 represents a hydrogen atom, a chlorine atom, a bromine atom, or an iodine atom; X 1 and X 2 are not simultaneously hydrogen atoms; and R 1 has the same meaning as defined in formula (3)] with a reducing agent represented by formula (2): €?€?€?€?€?€?€?€?M 1 BH m R 2 n (2-1) or M 2 (BH m R 2 n ) 2 €?€?€?€?€?(2-2) [wherein M 1 represents an alkali metal atom; M 2 represents an alkaline earth metal atom or a zinc atom; R 2 represents, for example, a hydrogen atom; m represents an integer from 1 to 4; n represents an integer from 0 to 3; and the sum of m and n is 4] in the presence of an aprotic polar solvent, and a Lewis acid such as a halide of an atom selected from among, for example, boron, magnesium, and aluminum.