130340-04-4

Usage

Uses

Used in Pharmaceutical Industry:
Trans-2-Fluoro-cyclopropanecarboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique cyclopropane ring structure allows for the creation of novel drug molecules with potential therapeutic applications. trans-2-Fluoro-cyclopropanecarboxylic acid's reactivity also facilitates the development of new chemical entities with improved pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical sector, trans-2-Fluoro-cyclopropanecarboxylic acid serves as an essential intermediate for the production of pesticides and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness in controlling pests and diseases, thereby contributing to increased agricultural productivity and food security.
Safety Precautions:
Given its potential corrosiveness and harmful effects if ingested or inhaled, it is crucial to handle trans-2-Fluoro-cyclopropanecarboxylic acid with care. Proper safety measures, including the use of personal protective equipment and adherence to safe laboratory practices, should be implemented during its manipulation and storage.
Storage Conditions:
To ensure the stability and safety of trans-2-Fluoro-cyclopropanecarboxylic acid, it should be stored in a cool, well-ventilated area, away from sources of ignition and incompatible substances. This will help prevent any accidental reactions or degradation of the compound, ensuring its integrity for use in various applications.

InChI:InChI=1S/C4H5FO2/c5-3-1-2(3)4(6)7/h2-3H,1H2,(H,6,7)/t2-,3-/m0/s1

Upstream product

• 137081-42-6 2-chloro-2-fluorocyclopropane carboxylic acid 
• 152237-14-4 tert-butyl 2-fluoro-cyclopropane-1-carboxylate 

Downstream Products

• 127199-12-6 2-Fluoro-cyclopropanecarboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 169884-67-7 (rac-(1R,2S)-2-fluorocyclopropyl)methanol 
• 185225-82-5 (±)-trans-2-fluorocyclopropanecarbonyl chloride 

Relevant academic research and scientific papers

PROCESS FOR PRODUCING 1,2-CIS-2-FLUOROCYCLOPROPANE-1-CARBOXYLIC ESTER COMPOUND

Provided is an industrially applicable process for producing 1,2-cis-2-fluorocyclopropane-1-carboxylic ester. A process for producing a compound represented by formula (3): [wherein R 1 represents, for example, a C1-C8 alkyl group], which process includes reacting a compound represented by formula (1) : [wherein X 1 represents a hydrogen atom, a chlorine atom, a bromine atom, or an iodine atom; X 2 represents a hydrogen atom, a chlorine atom, a bromine atom, or an iodine atom; X 1 and X 2 are not simultaneously hydrogen atoms; and R 1 has the same meaning as defined in formula (3)] with a reducing agent represented by formula (2): €?€?€?€?€?€?€?€?M 1 BH m R 2 n (2-1) or M 2 (BH m R 2 n ) 2 €?€?€?€?€?(2-2) [wherein M 1 represents an alkali metal atom; M 2 represents an alkaline earth metal atom or a zinc atom; R 2 represents, for example, a hydrogen atom; m represents an integer from 1 to 4; n represents an integer from 0 to 3; and the sum of m and n is 4] in the presence of an aprotic polar solvent, and a Lewis acid such as a halide of an atom selected from among, for example, boron, magnesium, and aluminum.

Fluorinated cyclopropanecarboxylic acids and their derivatives

The addition of halofluorocarbenes such as :CF2, :CClF or :CBrF, generated from the appropriate halofluoromethanes with bases, to butadiene or isoprene gives the corresponding l-vinyl substituted halofluorocyclopropanes in moderate to good yield. The vinyl group facilitates the carbene addition and permits a subsequent wide derivatisation. Several transformations including hydroboration, oxidation and Curtius degradation are presented. Furthermore, replacement of the chlorine atom in 2-chloro-2-fluorocyclopropanecarboxylic acid derivatives by hydrogen is achieved catalytically with Raney nickel. This sequence provides a convenient route to mono-fluorine substituted cyclopropane carboxylic acids.