1303583-05-2

Upstream product

• 504-24-5 4-aminopyridine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1303588-54-6 7-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazepine 
• 15128-82-2 3-hydroxy-2-nitropyridine 
• 443956-08-9 6-bromo-2-nitropyridin-3-ol 
• 1303588-51-3 6-bromo-3-(3-bromopropoxy)-2-nitropyridine 
• 1303588-52-4 6-bromo-3-(3-bromopropoxy)pyridin-2-amine 
• 1303588-53-5 7-bromo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazepine 

Relevant academic research and scientific papers

BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.