13036-90-3Relevant academic research and scientific papers
Dinuclear zinc bis(thiosemicarbazone) complexes: Synthesis, in vitro anticancer activity, cellular uptake and DNA interaction study
Palanimuthu, Duraippandi,Samuelson, Ashoka G.
, p. 152 - 161 (2013)
Four dinucleating bis(thiosemicarbazone) ligands and their zinc complexes have been synthesized and characterized by multinuclear NMR (1H and 13C), IR, UV-Vis, ESI-MS and fluorescence spectroscopic techniques. Their purity was assessed by elemental analysis. Cytotoxicity was tested against five human cancer cell lines using the sulphorhodamine B (SRB) assay, where one of the complexes, 1,3-bis{biacetyl-2′-(4″-N- pyrrolidinylthiosemicarbazone)-3′-(4″-N- pyrrolidinylthiosemicarbazone)zinc(II)}propane (6), was found to be quite cytotoxic against MCF-7 (breast cancer) and HepG2 (hepatoma cancer) cell lines, with a potency similar to that of the well known anticancer drug adriamycin. It is evident from the cellular uptake studies that the uptake is same for the active complex 6 and the inactive complex 8 (1,6-bis{biacetyl-2′- (4″-N-pyrrolidinylthiosemicarbazone)-3′-(4″-N- pyrrolidinylthiosemicarbazone)zinc(II)}hexane) in MCF-7 and HepG2 cell lines. In vitro DNA binding and cleavage studies revealed that all complexes bind with DNA through electrostatic interaction, and cause no significant cleavage of DNA.
Compound heavy metal chelating agent containing dithiocarboxylate functionalized ethoxylated pentaerythritol core hyperbranched polymer
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Paragraph 0039-0041, (2020/12/13)
A compound heavy metal chelating agent, which relates to the field of chemical and environmental protection technology, includes dithiocarboxylate functionalized ethoxylated pentaerythritol core hyperbranched polymer and alkylene diamine-N,N′-sodium bisdithiocarboxylate with a molar ratio in a range of 1:1.0 to 1:10.0. The two different structural types of components have the synergistic positive effect. While chelating heavy metals, the compound heavy metal chelating agent alternately combine with heavy metals to form insoluble chelating super-molecular deposits, which has both chelation and flocculation functions. The compound heavy metal chelating agent provided by the present invention is able to reach the standard for treating heavy metal wastewater, and especially low concentration heavy metal wastewater. It has a wide adaptability range, and does not need to add coagulant. Moreover, it is simple in preparation method, easily available for raw materials, low in cost, and easy to be industrialized.
Hexamethylenetetrathiocarbamic acid or salt thereof, method for producing same, and solution containing the hexamethylenetetrathiocarbamic acid or salt thereof
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Paragraph 0028-0033; 0040-0045; 0052-0059, (2019/12/02)
The invention relates to hexamethylenetetrathiocarbamic acid or salt thereof, a preparation method of the hexamethylenetetrathiocarbamic acid or salt thereof and a solution containing the hexamethylenetetrathiocarbamic acid or salt thereof, and belongs to the technical field of sewage treatment. According to the hexamethylenetetrathiocarbamic acid or the salt thereof, the structural formula of thehexamethylenetetrathiocarbamic acid is shown as a formula I shown in the specification, the structural formula of the hexamethylenetetrathiocarbamate is shown as a formula II or a formula III shown in the specification. In the formulas, M is independently selected from Na, K or NH4. The hexamethylenetetrathiocarbamic acid shown in the formula I is used together with an alkali, and thehexamethylenetetrathiocarbamate shown in the formula II is used together with an alkali. The hexamethylenetetrathiocarbamic acid or salt thereof shown as the formula I, the formula II and the formulaIII has excellent capturing capability on heavy metal ions, can effectively capture nickel, lead and other heavy metal ions, and is low in dosage, low in smell and safe and environment-friendly to use.
