56473-15-5

Upstream product

• 5586-70-9 hexamethylene 1,6-diisothiocyanate 
• 21494-66-6 3-[6-(4-oxo-2-thioxothiazolidin-3-yl)hexyl]-2-thioxothiazolidin-4-one 
• 45131-67-7 N,N'-(hexamethylene)bisdithiocarbamic acid 
• 871-67-0 disodium hexamethylenetetrathiocarbamate 
• 7803-57-8 hydrazine hydrate 
• 75-15-0 carbon disulfide 
• 124-09-4 1,6-Hexanediamine 
• 13208-75-8 N,N'-hexamethylenebis(2-thioxo-1,3-thiazin-2-one) 
• 822-06-0 Hexamethylene diisocyanate 

Downstream Products

• 101633-18-5 S,S'-dibenzyl-4,4'-hexanediyl-bis-iso thiosemicarbazide; dihydrochloride 
• 56473-22-4 C₂₂H₂₆Br₂N₆S₂ 
• 56473-37-1 1,1'-Di(m-brom-benzoyl)-4,4'-hexamethylen-bis(thiosemicarbazid) 
• 56473-25-7 C₂₂H₂₆Cl₂N₆S₂ 
• 56473-61-1 C₂₄H₃₄N₈S₄ 
• 56473-39-3 1,1'-Di(m-Chlor-benzoyl)-4,4'-hexamethylen-bis(thiosemicarbazid) 
• 56602-52-9 C₂₆H₃₄N₈O₂S₂ 
• 56473-21-3 C₂₂H₂₈N₆S₂ 
• 56473-36-0 1,1'-Dibenzoyl-4,4'-hexamethylen-bis(thiosemicarbazid) 
• 56473-62-2 C₂₂H₃₀N₈S₄ 
• 56473-63-3 C₂₂H₂₈Cl₂N₈S₄ 
• 56473-33-7 C₂₄H₂₈N₆O₄S₂ 
• 56473-42-8 1,1'-Di(p-nitro-benzoyl)-4,4'-hexamethylen-bis(thiosemicarbazid) 
• 56473-23-5 C₂₂H₂₆Br₂N₆S₂ 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: Structure-activity relationship studies on their anti-proliferative and iron chelation efficacy

Thiosemicarbazone chelators represent an exciting class of biologically active compounds that show great potential as anti-tumor agents. Our previous studies demonstrated the potent anti-tumor activity of the 2'-benzoylpyridine thiosemicarbazone series. W

Dinuclear zinc bis(thiosemicarbazone) complexes: Synthesis, in vitro anticancer activity, cellular uptake and DNA interaction study

Four dinucleating bis(thiosemicarbazone) ligands and their zinc complexes have been synthesized and characterized by multinuclear NMR (1H and 13C), IR, UV-Vis, ESI-MS and fluorescence spectroscopic techniques. Their purity was assessed by elemental analysis. Cytotoxicity was tested against five human cancer cell lines using the sulphorhodamine B (SRB) assay, where one of the complexes, 1,3-bis{biacetyl-2′-(4″-N- pyrrolidinylthiosemicarbazone)-3′-(4″-N- pyrrolidinylthiosemicarbazone)zinc(II)}propane (6), was found to be quite cytotoxic against MCF-7 (breast cancer) and HepG2 (hepatoma cancer) cell lines, with a potency similar to that of the well known anticancer drug adriamycin. It is evident from the cellular uptake studies that the uptake is same for the active complex 6 and the inactive complex 8 (1,6-bis{biacetyl-2′- (4″-N-pyrrolidinylthiosemicarbazone)-3′-(4″-N- pyrrolidinylthiosemicarbazone)zinc(II)}hexane) in MCF-7 and HepG2 cell lines. In vitro DNA binding and cleavage studies revealed that all complexes bind with DNA through electrostatic interaction, and cause no significant cleavage of DNA.

Synthesis and characterization of new thiazolidin-4-one derivatives

The synthesis of some new functionalized thiazolidin-4-one derivatives has been described. The N-substituted-thiosemicarbazides 3a-3i were obtained though the reaction of alkylamines 2a-2i, carbon disulfide, and hydrazine hydrate. The condensation reaction between 3a-3i and 4-amino-2-methanesulfanylpyrimidine-5- carboxaldehyde 1 afforded the thiosemicarbazones 4a-4i. The corresponding thiazolidin-4-ones 5a-5i were prepared by cyclization of 4a-4i with ethyl bromoacetate. The structures of the final products were confirmed by IR, 1H NMR, 13C NMR, and HRMS.

Preparative technique for synthesizing 4-alkyl(aryl)thiosemicarbazides

The possibility is considered of making shorter the technological process of synthesizing 4-alkyl (aryl)thiosemicarbazides in an anhydrous medium in the stage of formation of intermediate dithiocarbaminates.