130369-33-4Relevant articles and documents
NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
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Page/Page column 96, (2021/12/28)
The present invention relates to compounds of formula (I), or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein said compound of formula (I) comprises at least one covalently bound -ONO2 or -ONO moiety and at most four covalently bound -ONO2 or -ONO moieties, and wherein AR, R1, X, R3 and R4 are as defined in claim 1; and pharmaceutical compositions thereof, and their use in methods of treating or preventing a disease alleviated by inhibition of PDE5 in a human or in a non-human mammal.
Synthesis of 2-azaspiro[3.3]heptane-derived amino acids: Ornitine and GABA analogues
Radchenko, Dmytro S.,Grygorenko, Oleksandr O.,Komarov, Igor V.
scheme or table, p. 515 - 521 (2010/11/04)
Synthesis of 6-amino-2-azaspiro[3.3]heptane-6-carboxylic acid and 2-azaspiro[3.3]heptane-6-carboxylic acid was performed. Both four-membered rings in the spirocyclic scaffold were constructed by subsequent ring closure of corresponding 1,3-bis-electrophil
Synthesis of conformationally restricted glutamic acid analogs based on the spiro[3.3]heptane scaffold
Radchenko, Dmytro S.,Grygorenko, Oleksandr O.,Komarov, Igor V.
experimental part, p. 2924 - 2930 (2009/07/04)
A library of isomeric glutamic acid analogs based on the spiro[3.3]heptane skeleton is designed. Two members of the library, (R)- and (S)-2-amino-spiro[3.3]heptane-2,6-dicarboxylic acid hydrochlorides, were synthesized. The stereochemistry of the synthesi