13040-77-2

Usage

Uses

Used in Coordination Chemistry:
6-CHLORO-2,2'-BIPYRIDINE is used as a ligand for its ability to coordinate with a range of metal ions, facilitating the creation of novel catalysts and materials with enhanced properties.
Used in Organometallic Chemistry:
In organometallic chemistry, 6-CHLORO-2,2'-BIPYRIDINE is utilized as a ligand to stabilize organometallic complexes, which are essential in various catalytic processes and materials development.
Used in Catalysis:
6-CHLORO-2,2'-BIPYRIDINE is employed as a ligand in the design of catalysts, contributing to the efficiency and selectivity of chemical reactions in various industrial applications.
Used in Pharmaceutical Applications:
6-CHLORO-2,2'-BIPYRIDINE is used as a starting material or intermediate in the synthesis of new pharmaceutical compounds, leveraging its chemical properties to develop potential drugs for various therapeutic areas.
Used in Materials Science:
6-CHLORO-2,2'-BIPYRIDINE is applied in the development of new materials, such as sensors, optoelectronic devices, and advanced catalysts, due to its unique coordination chemistry properties.

Upstream product

• 33421-43-1 2,2'-bipyridyl N-oxide 
• 21970-13-8 (pyridin-2-yl)magnesium bromide 
• 87512-28-5 2-chloro-6-methylsulfinyl pyridine 
• 101001-90-5 <2,2'-bipyridin>-6(1H)-one 
• 109-09-1 2-chloropyridine 
• 109-04-6 2-bromo-pyridine 
• 263698-99-3 2-chloro-6-(tributylstannyl)pyridine 
• 366-18-7 [2,2]bipyridinyl 
• 2402-78-0 2,6-dichloropyridine 
• 5029-67-4 2-iodopyridine 
• 652148-92-0 2-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 108-86-1 bromobenzene 
• 5140-72-7 2-bromo-6-chloro-pyridine 
• 17997-47-6 2-tri-n-butylstannylpyridine 

Downstream Products

• 152194-39-3 6-(diphenylphosphino)-2,2'-bipyridine 
• 4392-83-0 2,2':6',2'':6'',2'''-quaterpyridine 
• 178039-84-4 6-amino-2-2’-pyridylbipyridine 
• 10495-73-5 2-bromo-6-(pyridin-2-yl)pyridine 
• 135853-33-7 6-(1H-pyrazol-1-yl)-2,2'-bipyridine 
• 239798-76-6 6-mercapto-2,2'-bipyridine 
• 1200396-63-9 ethyl 2,3,4-tri-O-benzyl-6-O-(2,2'-bipyridin-6-yl)-1-thio-β-D-glucopyranoside 
• 1223063-81-7 6-fluoro-2,2′-bipyridine 
• 1192424-21-7 C₂₂H₂₈N₄O₂S 
• 942274-96-6 6-(2-acetylphenyl)-2,2'-bipyridine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Novel DNA binding agents: Hydrazone-based helical trinuclear Ag complexes

Using the hydrazone linker and the self-assembly, functionalized Ag complexes with a helical structure showed a 2.96 A distance between metal-metal bonds, well-aligned aromatic rings, and the strong affinity toward DNA.

Syntheses and crystal structures of two self-assembled dizinc(II) helicates with novel hydrazone linked polypyridyl ligands

The rationally designed polydentate ligands, L1 and L2, based on the pyridinyl moiety and the hydrazone fragment have been synthesized to coordinate zinc(II) ions. We utilize pyridine as a rigid core connecting two bipyridines as ligand building blocks with a hydrozone linker for the L1. The L2 has a reversed design in which a bipyridine was used as a hinging-available building block of the ligand core, connecting two pyridazine arms with a hydrazone linker. Two novel helical dizinc(II) complexes were obtained by the reaction of L1 and L2 with zinc(II) perchlorate in acetonitrile. The structures of both helicates were confirmed by X-ray diffractometry. Single-stranded helicate Zn2L1 contains two zinc ions bridged by an oxygen atom. Except for the L2 ligand, no other bridging species were found between the two zinc ions in the double-stranded helicate Zn2L2 2. The self-assembling process of helicate Zn2L1 in solution state was studied by UV–Vis spectrometric titration experiments. The stepwise formation constants imply a slightly positive cooperative behavior for the formation of helicates.

Micelle-Enabled Suzuki-Miyaura Cross-Coupling of Heteroaryl Boronate Esters

We report a micellar protocol for Suzuki-Miyaura cross-coupling of heteroaryl boronic esters with aryl or heteroaryl halides. The micellar catalysis enables this coupling reaction to run under mild conditions, which avoids the decomposition of heteroaryl boronate esters and allows for high chemoselectivity for cross-coupling reaction with 6-chloropridine-2-boronic ester. The micellar protocol expands the scope of the cross-coupling reaction with challenging heteroaryl boronic esters and complements the existing cross-coupling methods for construction of heterobiaryl building blocks.

Rhodium(iii)-catalyzed switchable C-H acylmethylation and annulation of 2,2′-bipyridine derivatives with sulfoxonium ylides

A novel protocol for Rh(iii)-catalyzed switchable C-H acylmethylation and annulation of 2,2′-bipyridine derivatives with sulfoxonium ylides is reported. This protocol provides a facile approach to synthesize structurally diverse acylmethylated 2,2′-bipyridine derivatives and acyl pyrido[2,3-a]indolizines with a broad range of functional group tolerance.

METHOD FOR COUPLING HALOGENATED PYRIDINE COMPOUND WITH HALOGENATED AROMATIC COMPOUND

There is a demand for the development of a technique according to which a reaction for coupling a halogenated pyridine compound with a halogenated aromatic compound can be performed in a simple manner through a small number of steps without using expensive agents such as a palladium catalyst. A method for coupling a halogenated pyridine compound with a halogenated aromatic compound includes a step of coupling a halogenated pyridine compound with a halogenated aromatic compound to obtain a pyridine compound by reacting, in a reaction solvent, the halogenated pyridine compound and the halogenated aromatic compound with a solution containing an alkali metal.

A novel approach for rhodium(iii)-catalyzed C-H functionalization of 2,2′-bipyridine derivatives with alkynes: A significant substituent effect

We described a novel approach for the C-H functionalization of 2,2′-bipyridine derivatives with alkynes. DFT calculations and experimental data showed a significant substituent effect at the 6-position of 2,2′-bipyridine, which weakened the adjacent N-Rh bond and provided the possibility of subsequent rollover cyclometalation, C-H activation, and functionalization.

Synthesis, characterisation and application of iridium(III) photosensitisers for catalytic water reduction

The synthesis of novel, monocationic iridium(III) photosensitisers (Ir-PSs) with the general formula [IrIII(C^N)2(N^N)]+ (C^N: cyclometallating phenylpyridine ligand, N^N: neutral bidentate ligand) is described. The structures obtained were examined by cyclic voltammetry, UV/Vis and photoluminescence spectroscopy and X-ray analysis. All iridium complexes were tested for their ability as photosensitisers to promote homogeneously catalysed hydrogen generation from water. In the presence of [HNEt 3][HFe3(CO)11] as a water-reduction catalyst (WRC) and triethylamine as a sacrificial reductant (SR), seven of the new iridium complexes showed activity. [Ir(6-iPr-bpy)(ppy)2]PF 6 (bpy: 2,2′-bipyridine, ppy: 2-phenylpyridine) turned out to be the most efficient photosensitiser. This complex was also tested in combination with other WRCs based on rhodium, platinum, cobalt and manganese. In all cases, significant hydrogen evolution took place. Maximum turnover numbers of 4550 for this Ir-PS and 2770 for the Fe WRC generated in situ from [HNEt 3][HFe3(CO)11] and tris[3,5- bis(trifluoromethyl)phenyl]phosphine was obtained. These are the highest overall efficiencies for any Ir/Fe water-reduction system reported to date. The incident photon to hydrogen yield reaches 16.4 % with the best system. Copyright

COMPOUND HAVING NPY Y5 RECEPTOR ANTAGONIST ACTIVITY

This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 is hydrogen or substituted or unsubstituted alkyl, Ring A is monocyclic or bicyclic aromatic heterocycle, R3 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocycle, R4 is halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like, m is an integer between 0 and 2, n is an integer between 0 and 5, R is halogen, oxo, cyano, nitro, substituted or unsubstituted alkyl or the like, and p is an integer between 0 and 2 as novel compounds having NPY Y5 antagonistic activity.

COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY

This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 is hydrogen or substituted or unsubstituted alkyl, Ring A is monocyclic or bicyclic aromatic heterocycle, R3 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocycle, R4 is halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like, m is an integer between 0 and 2, n is an integer between 0 and 5, R is halogen, oxo, cyano, nitro, substituted or unsubstituted alkyl or the like, and p is an integer between 0 and 2 as novel compounds having NPY Y5 antagonistic activity.

4-(Pyridin-2-yl)thiazol-2-yl thioglycosides as bidentate ligands for oligosaccharide synthesis via temporary deactivation

This study focusses on a new concept for oligosaccharide synthesis based on 4-(pyridin-2-yl)thiazol-2-yl thioglycosides that can either act as effective glycosyl donors or can be deactivated by stable bidentate complexation with palladium(ii) bromide. The Royal Society of Chemistry.