130405-71-9

Basic information

• Product Name: (±)-ethyl 2-(4-chlorophenyl)propanoate
• CAS NO: 130405-71-9
• Molecular Weight: 212.676
• Mol File: 130405-71-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (±)-ethyl 2-(4-chlorophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-ethyl 2-(4-chlorophenyl)propanoate(130405-71-9)
• EPA Substance Registry System: (±)-ethyl 2-(4-chlorophenyl)propanoate(130405-71-9)

Safety Data

• Hazardous Substances Data: 130405-71-9(Hazardous Substances Data)

Upstream product

• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 74-88-4 methyl iodide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 106-39-8 bromochlorobenzene 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 140-88-5 ethyl acrylate 
• 64-17-5 ethanol 
• 938-95-4 2-(4-Chloro-phenyl)-propionic acid 
• 1073-67-2 4-vinylbenzyl chloride 
• 201230-82-2 carbon monoxide 

Downstream Products

• 180293-46-3 ethyl 2-(4-chlorophenyl)-2-fluoropropanoate 
• 938-95-4 2-(4-Chloro-phenyl)-propionic acid 
• 105879-63-8 (S)-4-chloro-α-methylphenylacetic acid 

Relevant articles and documents

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Synthesis and Applications of Unquaternized C-Bound Boron Enolates

A general and facile method to prepare unquaternized C-bound boron enolates by a ligand-controlled O-to-C isomerization is reported. Using this protocol, C-bound pinacolboron enolates have been isolated in pure form for the first time, and have been fully characterized by NMR spectroscopy and X-ray crystallography. In contrast to the general perception, such C-boron enolates are stable without coordinative saturation at the boron. Moreover, C-boron enolates present reactivities that are distinct from the O-boron enolates, and their applications in C-O and C-C bond formations are demonstrated.

Immobilization of palladium acetate on ionic liquid copolymerized polystyrene: A way to eliminate inhibiting effect of imidazolium chloride and enhance catalytic performance

Immobilization of palladium acetate on a novel polymeric support that is prepared by copolymerization of 3-butyl-1-vinylimidazolium chloride with styrene is demonstrated to be an effective way to eliminate inhibiting effect of imidazolium chloride and enhance catalytic performance. Copyright