13041-64-0

Basic information

• Product Name: methyl 4-methoxy-1-naphthoate
• Synonyms: methyl 4-methoxy-1-naphthoate
• CAS NO: 13041-64-0
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.23258
• Mol File: 13041-64-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 4-methoxy-1-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-methoxy-1-naphthoate(13041-64-0)
• EPA Substance Registry System: methyl 4-methoxy-1-naphthoate(13041-64-0)

Safety Data

• Hazardous Substances Data: 13041-64-0(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 13041-62-8 4-methoxy-1-naphthoic acid 
• 74-88-4 methyl iodide 
• 2216-69-5 1-Methoxynaphthalene 
• 90-15-3 α-naphthol 
• 67-56-1 methanol 
• 509-14-8 tetranitromethane 

Downstream Products

• 374926-08-6 2-(4-methoxynaphthalene-1-carbonyl)acetonitrile 

Relevant articles and documents

Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a clinically validated target for the treatment of type 2 diabetes mellitus (T2DM). To discover novel and potent DPP-4 inhibitors, three series of compounds were designed and synthesized in this study based on our previou

Light-initiated and thermal nitration reactions during photolysis of naphthalene/tetranitromethane or 1-methoxynaphthalene/tetranitromethane in dichloromethane

The photolysis of naphthalene or 1-methoxynaphthalene together with tetranitromethane in dichloromethane, using light with a cutoff at λ 2-promoted nitration (α/β ratio ca. 20). The adducts are formed by photochemical excitation of the CT complex between naphthalene and tetranitromethane, resulting in formation of the triad [ArH?+ NO2 (NO2)3C-] from which the observed chemistry develops by attack of trinitromethanide upon the radical cation. For 1-methoxynaphthalene, a representative of more highly reactive aromatics, the reaction is again photochemically initiated and again adducts seem to be responsible for the further development of thermal nitration reactions, apart from the NO2-induced reaction. Elimination of HNO2 from one of the 1,4-adducts induces a novel HNO2/tetranitromethane-dependent nitration process, shown separately to operate in the dark on reactive substrates. The aryltrinitromethane formed in this step is "hydrolyzed" to the corresponding carboxylic acid, 4-methoxy-1-naphthoic acid, under the anhydrous conditions prevailing during photolysis. Nitrous acid is a likely candidate as the proton source for this reaction. With an alcohol present, moderate yields (up to ≈50%) of alkyl 4-methoxy-1-naphthoates are obtained. From other adducts, nitro compounds are formed by elimination of nitroform. Trinitromethanide ion was shown to possess greatly differing reactivity (ratio >103) toward a model radical cation, tris(4-bromophenyl)aminium ion, in dichloromethane and acetonitrile, respectively.