130427-06-4Relevant academic research and scientific papers
Tin (IV) chloride-promoted reactions of β-dicarbonyl compounds with nitriles. Synthesis of aminopyridines and aminoquinolines
Veronese, Augusto C.,Callegari, Rosella,Salah, Suada Ahmed Ali
, p. 3485 - 3488 (1990)
β-Ketoesters and β-diesters react with β-enaminonitriles in the presence of stoichiometric amounts of tin (IV) chloride to give 4-aminopyridines and pyridones while they react with aromatic orthoaminonitriles to give 4-aminoquinolines and quinolones.
Environmentally benign synthesis of 4-aminoquinoline-2-ones using recyclable choline hydroxide
Sanap, Anita Kailas,Shankarling, Ganapati Subray
, p. 206 - 212 (2015/02/19)
Greener synthesis of 4-aminoquinoline-2-ones was achieved by intramolecular cyclization of 2-cyanophenylamide derivatives using biodegradable and recyclable choline hydroxide (ChOH). The reaction proceeds rapidly and affords the corresponding 4-aminoquinoline-2-ones with a good to excellent yield. The protocol has the advantage of easy workup, high yields, and an environmentally benign methodology compared to other reported methods. The simplicity of this method makes it an interesting alternative to other approaches.
Tin (IV) chloride-promoted synthesis of 4-aminopyridines and 4-aminoquinolines
Veronese, Augusto C.,Callegari, Rosella,Morelli, Carlo F.
, p. 12277 - 12284 (2007/10/02)
Ortho-aminobenzonitriles 1 react with β-ketoesters and alkyl malonates, in the presence of stoichiometric amounts of tin (IV) chloride, to give 4-aminoquinolines 2 and 4-amino-2-quinolones 3 respectively. Similarly β-enaminonitriles 7 afford 4-aminopyridi
