130475-84-2

Upstream product

• 615-83-8 2-bromo-pentanoic acid ethyl ester 
• 110164-06-2 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione 
• 118252-16-7 ethyl (4-methoxycarbonyl)thiophene-3-carbamate 
• 39978-14-8 methyl 3-amino-4-thiophenecarboxylate hydrochloride 
• 14660-52-7 ethyl 5-bromovalerate 

Downstream Products

• 130475-23-9 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-cycloocta[cd]indene-3,5,10-trione 
• 130475-82-0 3-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]-5-methyl-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]-propanoic acid sodium salt 
• 130475-85-3 5-(3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-thieno[3,4-d]pyrimidin-1-yl)-pentanoic acid 

Relevant academic research and scientific papers

RING-FUSED THIENOPYRIMIDINEDIONE DERIVATIVES

The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and as such are useful as cardiovascular agents.

Thiophene Systems. 11. The Synthesis of Novel Thieno Tricyclic Ring Systems

The synthesis of thieno tricyclic compounds is described.The N-1 alkylation of I produced the alkanoic ester precursors.After hydrolysis, the corresponding carboxylic acids were cyclized to the title compounds II.This cyclization step was accomp