130515-56-9Relevant academic research and scientific papers
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
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, (2021/11/26)
The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.
The chemistry of 2′,3′-seconucleosides IV. Synthesis and reactions of 3′-azido-2′,3′-dideoxy-2′,3′- secothymidine and related analogues
Kumar, Ajit,Walker, Richard T.
, p. 3101 - 3110 (2007/10/02)
The synthesis of a series of 2,3-seconucleoside analogues related to nucleosides previously shown to possess anti-HIV activity is described. Using strategies to distinguish between the three primary hydroxyl groups of a 2,3-seconucleoside, 3-azido-2,3-dideoxy-2,3-secothymidine and 2,3-dideoxy-2,3-secothymidine have been prepared. These compounds, several of the intermediates in their synthesis, as well as O22-anhydro-3-azido-3-deoxy-2,3-secothymidine and several 2,3-secouridine analogues have been tested for their ability to prevent infection of cells by HIV. None showed any significant toxicity or antiviral activity.
