2073-43-0

Usage

Uses

Used in Research Applications:
Uridine, 5-methyl-2',3'-O-(1-methylethylidene)is used as a research tool for studying the effects of nucleoside modifications on RNA structure, function, and stability. It can help researchers understand the role of modified nucleosides in RNA biology and their potential impact on various cellular processes.
Used in Pharmaceutical Development:
Uridine, 5-methyl-2',3'-O-(1-methylethylidene)is used as a starting material for the development of nucleotide analogs with potential therapeutic applications. These analogs may be designed to target specific viral or cellular processes, offering new treatment options for viral infections or other diseases.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Uridine, 5-methyl-2',3'-O-(1-methylethylidene)can be incorporated into drug delivery systems to improve the efficacy and bioavailability of nucleotide analogs. This may involve the use of nanoparticles or other carriers to facilitate targeted delivery to specific cells or tissues, enhancing the therapeutic potential of these modified nucleosides.
Further study is needed to fully understand the effects and potential uses of this modified nucleoside, as its unique chemical properties and potential impact on RNA biology may offer new insights and opportunities in both research and medicine.

Upstream product

• 149204-06-8 1,2,3,4-tetrahydro-1-(2',3'-O-isopropylidenethymidyl)-quinoline 

Downstream Products

• 126543-48-4 5'-O-benzoyl-2',3'-O-isopropylidene-5-methyluridine 
• 1463-10-1 5-Methyluridine 
• 917482-61-2 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine 
• 86387-00-0 (5S)-5'-O-benzoyl-2',3'-O-isopropylidene-5-methyl-5,6-dihydrouridine 
• 86386-99-4 (5R)-5'-O-benzoyl-2',3'-O-isopropylidene-5-methyl-5,6-dihydrouridine 
• 86386-96-1 (5S)-2',3'-O-isopropylidene-5-methyl-5'-O-(p-tosyl)-5,6-dihydrouridine 
• 86386-95-0 (5R)-2',3'-O-isopropylidene-5-methyl-5'-O-(p-tosyl)-5,6-dihydrouridine 
• 87818-00-6 2',3'-O-isopropylidene-5'-O-methoxymethyl-5-methyl-6-phenylthiouridine 
• 87818-13-1 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-6-phenylsulfanyl-1H-pyrimidine-2,4-dione 
• 50-89-5 thymidine 
• 1241404-77-2 (5S,SP)-1,2-O-isopropylidene-5-(4-fluorophenyl)-3,5-O-(5'-(2',3'-O-isopropiliden-5-metyluridinyl))phosphoryl-α-D-xylofuranose 
• 1241404-78-3 (5S,RP)-1,2-O-isopropylidene-5-(4-fluorophenyl)-3,5-O-(5'-(2',3'-O-isopropiliden-5-metyluridinyl))phosphoryl-α-D-xylofuranose 
• 1241404-79-4 (5R,SP)-1,2-O-isopropylidene-5-(4-fluorophenyl)-3,5-O-(5'-(2',3'-O-isopropiliden-5-metyluridinyl))phosphoryl-α-D-xylofuranose 
• 1241404-80-7 (5R,RP)-1,2-O-isopropylidene-5-(4-fluorophenyl)-3,5-O-(5'-(2',3'-O-isopropiliden-5-metyluridinyl))phosphoryl-α-D-xylofuranose 

Relevant academic research and scientific papers

Insight into the chemical mechanism of thymidylate synthase-catalyzed reaction through the evaluation of chemical models: The role of C6 sulfhydryl addition during the reductive elimination step of the reaction

Thymidylate synthase catalyzes the last step of the de novo synthesis of thymidine-5'-monophosphate (TMP), which has long been a target for the development of effective anticancer agents. Model compounds (15, 16, 17) were used to study the effect of C6 nucleophilic addition on the reductive elimination step of the TS-catalyzed reaction. Results suggest that C6 addition facilitates the reductive elimination of the H2folate moiety of the ternary intermediate (3). Therefore, the reaction pathway (pathway (b)) with the participation of C6 sulfhydryl addition during the reductive elimination process is the energetically favored process. Consequently, the elimination of the cysteine sulfhydryl group from the C6 position is the last step of the reaction before the dissociation of the products from the enzyme.