130516-25-5

Upstream product

• 110-65-6 1,4-dihydroxybut-2-yne 
• 100-51-6 benzyl alcohol 
• 71338-71-1 benzyl (E)-2-butenoate 
• 100-39-0 benzyl bromide 
• 5094-24-6 D,L-2-hydroxybutyric acid sodium salt 
• 71338-71-1 benzyl crotonate 

Downstream Products

• 130516-27-7 (S)-1-Benzyl-5-[1-benzyloxycarbonyl-prop-(Z)-ylidene]-pyrrolidine-2-carboxylic acid methyl ester 
• 1208982-37-9 benzyl (R)-2-(diphenylacetyloxy)butanoate 
• 130516-26-6 2-Trifluoromethanesulfonyloxy-butyric acid benzyl ester 

Relevant academic research and scientific papers

An effective cis-β-octahedral Mn(iii) SALPN catalyst for the Mukaiyama-Isayama hydration of α,β-unsaturated esters

Two cis-β-MnIIISALPN catalysts were synthesised and tested in the Mukaiyama-Isayama hydration of α,β-unsaturated esters. The MnIIIEtOSALPN(acac) complex 7 is the most active and catalyses hydration with little or no detectable undesired alkene reduction. This catalyst is superior for alkene hydration compared to the originally reported Mn(dpm)3 catalyst.

Matrix metalloprotease inhibitors

Compounds of formula (I): STR1 as single stereoisomers or mixtures thereof and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as interstitial collagenases, and are useful in the treatment of mammals having disease states alleviated by the inhibition of such matrix metalloproteases, for example arthritic diseases or bone resorption disease, such as osteoporosis.

MATRIX METALLOPROTEASE INHIBITORS

Compounds of formula (I): STR1 as single stereoisomers or mixtures thereof and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as interstitial collagenases, and are useful in the treatment of mammals having disease states alleviated by the inhibition of such matrix metalloproteases, for example arthritic diseases or bone resorption diseases, such as osteoporosis.

A New and Facile Method for the Direct Preparation of α-Hydroxycarboxylic Acid Esters from α,β-Unsaturated Carboxylic Acid Esters with Molecular Oxygen and Phenylsilane Catalyzed by Bis(dipivaloylmethanato)manganese(II) Complex

In the presence of a catalytic amount of bis(dipivaloylmethanato)manganese(II) complex, the oxygenation of benzyl crotonate with molecular oxygen and phenylsilane proceeds smoothly under a mild condition to give benzyl 2-hydroxybutyrate in high yield.The reaction provides a new and convenient method for the direct preparation of various α-hydroxycarboxylic acid esters starting from α,β-unsaturated carboxylic acid esters.The influence of substituents of olefins on regioselectivity is also studied.