130523-04-5Relevant articles and documents
Chemistry of Ginkgolides, IV. Synthesis of Ginkgolide B from Ginkgolide C
Weinges, Klaus,Schick, Hartmut
, p. 81 - 83 (2007/10/02)
The reaction of ginkgolide C (3) with tert-butylchlorodiphenylsilane results exclusively in the formation of the 1-O-tert-butyldiphenylsilyl ether 5, which when treated with O-phenylchlorothioformate leads to the 7-phenyloxythiocarbonyl derivative 6.The reduction of 6 with tributyltin hydride/AIBN yields the 1-O-tert-butyldiphenylsilyl ether 7 of ginkgolide B (2).Removal of the silyl protective group with tetrabutylammonium fluoride gives pure ginkgolide B (2).The structures of the reaction products were confirmed by analytical and spectroscopic methods.
