130533-09-4

Upstream product

• 143-33-9 sodium cyanide 
• 100-52-7 benzaldehyde 
• 2393-23-9 4-methoxy-benzylamine 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 130533-00-5 N-(4-methoxybenzyl)-N-(1-cyanobenzyl)-2-bromoacetamide 
• 130533-12-9 1-(4-methoxybenzyl)-4-phenyl-2-oxoazetidine-4-carbonitrile 
• 130533-03-8 4-phenyl-2-oxoazetidine-4-carbonitrile 
• 5661-55-2 4-phenylazetidin-2-one 
• 72867-49-3 N-(Cyano-phenyl-methyl)-N-(4-methoxy-benzyl)-benzamide 

Relevant academic research and scientific papers

Synthesis of α-aminonitriles under mild catalytic, metal-free conditions

α-Aminonitriles have been synthesized by a Strecker synthesis from aldehydes and ketones under mild catalytic, metal-free conditions. Aromatic aldehydes (1 equiv) were reacted with aromatic and 1 or 2 aliphatic amines (1 equiv) in EtOH containing 3 mol %

One-pot synthesis of polysubstituted pyrrolidines from aminonitriles

α-Aminonitriles with a mono- or unsubstituted amino group as well as α-(alkylideneamino)nitriles can be employed as easily accessible α-aminocarbanion equivalents. Their α-deprotonation yields stabilized carbanions, which undergo smooth 1,4-addition to α,β- unsaturated carbonyl compounds. The resulting δ-keto-α-aminonitriles can be reductively cyclized to form polysubstituted pyrrolidines. Georg Thieme Verlag Stuttgart.

Decyanation of 2-Oxoazetidine-4-carbonitriles as a New Route to (4S)-4--azetidin-2-one, an Intermediate for the Synthesis of 1β-Methylcarbapenem Antibiotics

Base-catalysed cyclisation of the α-bromoacetamides derived from aminonitriles gave 4-alkyl- and 4-aryl-2-oxoazetidine-4-carbonitriles in high yield, whose cyano group was removed with sodium in liquid ammonia. (3R)-2-(4-Methoxybenzylamino)-3-benzyloxy-me