130533-09-4Relevant articles and documents
Synthesis of α-aminonitriles under mild catalytic, metal-free conditions
Nammalwar, Baskar,Fortenberry, Chelsea,Bunce, Richard A.
supporting information, p. 379 - 381 (2014/01/06)
α-Aminonitriles have been synthesized by a Strecker synthesis from aldehydes and ketones under mild catalytic, metal-free conditions. Aromatic aldehydes (1 equiv) were reacted with aromatic and 1 or 2 aliphatic amines (1 equiv) in EtOH containing 3 mol %
Decyanation of 2-Oxoazetidine-4-carbonitriles as a New Route to (4S)-4--azetidin-2-one, an Intermediate for the Synthesis of 1β-Methylcarbapenem Antibiotics
Shirai, Masashi,Nishiwaki, Tarozaemon
, p. 2018 - 2031 (2007/10/02)
Base-catalysed cyclisation of the α-bromoacetamides derived from aminonitriles gave 4-alkyl- and 4-aryl-2-oxoazetidine-4-carbonitriles in high yield, whose cyano group was removed with sodium in liquid ammonia. (3R)-2-(4-Methoxybenzylamino)-3-benzyloxy-me