130600-32-7Relevant academic research and scientific papers
Design and synthesis of potent antitumor 5,4'-diaminoflavone derivatives based on metabolic considerations
Akama, Tsutomu,Ishida, Hiroyuki,Shida, Yasushi,Kimura, Uichiro,Gomi, Katsushige,Saito, Hiromitsu,Fuse, Eiichi,Kobayashi, Satoshi,Yoda, Nobuyuki,Kasai, Masaji
, p. 1894 - 1900 (2007/10/03)
Recently, we reported that 5,4'-diaminoflavone (1) exhibits potent and specific growth-inhibitory activity against the estrogen receptor (ER)- positive human breast cancer cell line MCF-7. However, when compound 1 was incubated with S-9 mix, its metabolit
