130611-26-6

Basic information

• Product Name: ethyl 4-(2-methoxyethoxy)-3-oxobutanoate
• Synonyms: Butanoic acid, 4-(2-methoxyethoxy)-3-oxo-, ethyl ester; Ethyl 4-(2-methoxyethoxy)-3-oxobutanoate
• CAS NO: 130611-26-6
• Molecular Formula: C₉H₁₆O₅
• Molecular Weight: 204.2203
• Mol File: 130611-26-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 281.5°C at 760 mmHg
• Flash Point: 129.8°C
• Density: 1.072g/cm³
• Vapor Pressure: 0.00356mmHg at 25°C
• Refractive Index: 1.428
• PKA: 9.83±0.46(Predicted)
• CAS DataBase Reference: ethyl 4-(2-methoxyethoxy)-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(2-methoxyethoxy)-3-oxobutanoate(130611-26-6)
• EPA Substance Registry System: ethyl 4-(2-methoxyethoxy)-3-oxobutanoate(130611-26-6)

Safety Data

• Hazardous Substances Data: 130611-26-6(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(2-methoxyethoxy)-3-oxobutanoate is a chemical compound with the molecular formula C10H18O5. It is also known as ethyl acetylacetate glycol. ethyl 4-(2-methoxyethoxy)-3-oxobutanoate is commonly used as a solvent in various industries, including pharmaceuticals, coatings, and adhesives. It is a colorless liquid with a sweet, fruity odor and is highly flammable. Ethyl 4-(2-methoxyethoxy)-3-oxobutanoate is a versatile compound and is often used as a chemical intermediate in the synthesis of other organic compounds. Additionally, it is known for its high solvency power and is used as a solvent for a wide range of substances.

Upstream product

• 16024-56-9 2-(2-methoxyethoxy)acetic acid 
• 1071-46-1 hydrogen ethyl malonate 
• 2033-24-1 cycl-isopropylidene malonate 
• 16024-55-8 2-(2-methoxyethoxy)acetyl chloride 
• 6148-64-7 ethyl potassium malonate 
• 109-86-4 2-methoxy-ethanol 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 79522-43-3 4-(2,3-Dichloro-phenyl)-2-(2-methoxy-ethoxymethyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 

Relevant articles and documents

HETEROCYCLIC AZA COMPOUNDS

The invention relates to heterocyclic aza compounds as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET(A) receptor selectivity

Endothelins, ET-1, ET-2, and ET-3 are potent vasoconstricting and mitogenic 21-amino acid bicyclic peptides, which exert their effects upon binding to the ET(A) and ET(B) receptors. The ET(A) receptor mediates vasoconstriction and smooth muscle cell proliferation, and the ET(B) receptor mediates different effects in different tissues, including nitric oxide release from endothelial cells, and vasoconstriction in certain vascular cell types. Selective antagonists of endothelin receptor subtypes may prove useful in determining the role of endothelin in various tissue types and disease states, and hence as therapeutic agents for such diseases. The pyrrolidine carboxylic acid A-127722 has been disclosed as a potent and ET(A)-selective antagonist, and is currently undergoing clinical trials. In our efforts to find antagonists with altered selectivity (ET(A)-selective, ET(B)-selective, or nonselective), we investigated the SAR of the 2-substituent on the pyrrolidine. Compounds with alkyl groups at the 2-position possessed ET(A) selectivity improved over A-127722 (1400-fold selective), with the best of these compounds showing nearly 19,000-fold selectivity. Copyright (C) 1999 Elsevier Science Ltd.