130626-88-9Relevant academic research and scientific papers
The Aryne aza-Diels-Alder Reaction: Flexible Syntheses of Isoquinolines
Castillo, Juan-Carlos,Quiroga, Jairo,Abonia, Rodrigo,Rodriguez, Jean,Coquerel, Yoann
supporting information, p. 3374 - 3377 (2015/07/15)
(Chemical Equation Presented). Two cascade reactions have been developed for the time-efficient preparation of a variety of functionalized aromatic heterocyclic products exhibiting an isoquinoline core. The approach is based on the normal electron-demand
Divergent chemo-, regio-, and diastereoselective normal electron-demand povarov-type reactions with α-oxo-ketene dienophiles
Galvez, Jaime,Castillo, Juan-Carlos,Quiroga, Jairo,Rajzmann, Michel,Rodriguez, Jean,Coquerel, Yoann
supporting information, p. 4126 - 4129 (2014/10/15)
The reactions between electron-rich 2-aza-dienes and α-oxo-ketenes derived from the Wolff rearrangement of 2-diazocycloalkane-1,3-diones chemo- and regioselectively produced spiro hydropyrid-4-ones with good to excellent diastereoselectivities. These reactions are likely to proceed via a domino Wolff/Friedel-Crafts/intramolecular Mannich process. Prolonged domino sequences also allowed the expeditious preparation of a series of pyrazolopyridine and pyridopyrimidine heterocycles.
Pyrazolopyridines I: Synthesis of some pyrazolo[3,4-b]pyridine-4- carboxylates
Maqbool, Tahir,Khan, Misbahul Ain,Khan, Muhammad Naeem,Elliott, Mark C.,Munawar, Munawar Ali,Nasrullah, Muhammad,Bhatti, Abdul Waheed,Nazeer, Areesha,Lin, Whei-Oh
, p. 7715 - 7718 (2013/09/23)
A series of ethyl 3-methyl-1-phenyl-6-aryl-1 H-pyrazolo[3,4-b]pyridine-4- carboxylates were prepared by the reaction of 5-amino-3-methyl-1-phenyl-1 H-pyrazole with various aromatic aldehydes and ethyl pyruvate. The structure elucidation of the prepared compounds was carried out by spectroscopic techniques (mass, IR, 1H and 13C NMR).
Synthesis of Benzylidenaminopyrazoles and Bispyrazolopyridines
Hennig, L.,Hofmann, J.,Alva-Astudillo, M.,Mann, G.
, p. 351 - 358 (2007/10/02)
5-Aminopyrazoles 1a-e react with aromatic aldehydes in boiling ethanol to yield azomethines 2a-n.Bispyrazolopyridines 7a-f are obtained by the reaction of 2a-f with an excess of aminopyrazole at higher temperatures via bisaminopyrazoles 5 and bispyrazolodihydropyridines 6.Structure and configuration of the products are assigned by n.m.r. spectroscopy.Reactions with replacement of the arylidene group on azomethine 2b suggest that the transformation of azomethines to bisaminopyrazoles occurs through a mechanism involving addition of the CH-acidic component, with subsequent elimination of aminopyrazole.
