380342-10-9

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 123-11-5 4-methoxy-benzaldehyde 
• 130626-88-9 [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-(5-methyl-2-phenyl-2H-pyrazol-3-yl)-amine 
• 35322-20-4 ethyl 3-(4-methoxybenzoyl)pyruvate 

Downstream Products

• 380193-14-6 C₂₁H₁₉N₅O₂ 

Relevant academic research and scientific papers

Pyrazolopyridines I: Synthesis of some pyrazolo[3,4-b]pyridine-4- carboxylates

A series of ethyl 3-methyl-1-phenyl-6-aryl-1 H-pyrazolo[3,4-b]pyridine-4- carboxylates were prepared by the reaction of 5-amino-3-methyl-1-phenyl-1 H-pyrazole with various aromatic aldehydes and ethyl pyruvate. The structure elucidation of the prepared compounds was carried out by spectroscopic techniques (mass, IR, 1H and 13C NMR).

Approach to the library of fused pyridine-4-carboxylic acids by combes-type reaction of acyl pyruvates and electron-rich amino heterocycles

A library of fused pyridine-4-carboxylic acids (including pyrazolo[3,4-b]pyridines, isoxazolo[5,4-b]pyridines, furo[2,3-b]pyridines, thieno[2,3-b]pyridines, and pyrido[2,3-d]pyrimidines) was generated by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles followed by hydrolysis of the ester. The library members were also demonstrated to undergo the standard combinatorial transformations including amide coupling and esterification, as well as less common heterocyclizations to 1,2,4-triazoles and 1,2,4-oxadiazoles.

Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series

The development of new drugs against Trypanosoma cruzi is still required since the only two drugs currently used cause severe side effects. In this work we described the synthesis, the in vitro biological evaluation, and the SAR results of 1H-pyrazolo[3,4